RET/PTC重排在伴有腹壁转移和宫颈甲状腺的卵巢恶性甲状腺肿引起的甲状腺乳头状癌中的应用:一例报告和文献复习。

IF 1.9 Q3 ENDOCRINOLOGY & METABOLISM
Maryam Kabootari, Reza Habibi Tirtashi, Azita Zadeh-Vakili, Maryam Zarkesh, Hossein Samadanifard, Shirin Haghighi, Fereidoun Azizi, Atieh Amouzegar
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引用次数: 1

摘要

背景:卵巢支柱瘤是指罕见的成熟囊性畸胎瘤,至少含有50%的甲状腺组织,恶性转化更为罕见。由于有关分子特征的数据有限,卵巢恶性甲状腺肿和宫颈甲状腺癌的同步发展也很少见,也知之甚少。本文首次报道了同时转移至腹壁和颈段甲状腺癌症的卵巢甲状腺肿RET/PTC1重排。病例介绍:我们描述了一名47岁的多生殖器女性,在评估异常子宫出血时发现双侧附件和下腹壁肿块。患者接受了子宫切除术、双侧输卵管卵巢切除术和腹壁肿块的手术切除。然后,病理评估显示卵巢甲状腺肿内的甲状腺乳头状癌(PTC)和腹壁纤维脂肪组织中的转移性PTC。此外,宫颈甲状腺体检和超声检查显示左叶内有结节。随后,进行了甲状腺全切除术,组织学检查显示PTC。此外,所有受影响的组织,即卵巢甲状腺肿、腹壁转移和宫颈甲状腺,都检测了BRAF和RAS突变以及RET/PTC 1重排。RET/PTC1重排在所有三个不同的位点中被鉴定。最后,经过六年的随访,患者没有复发或远处转移的迹象。结论:根据这些发现,卵巢恶性甲状腺肿可能为宫颈甲状腺癌提供线索,分子分析可为了解其潜在机制、肿瘤临床病理行为和预后提供有价值的信息。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

RET/PTC rearrangement in papillary thyroid carcinoma arising in malignant struma ovarii with abdominal wall metastasis and cervical thyroid gland: a case report and review of the literature.

RET/PTC rearrangement in papillary thyroid carcinoma arising in malignant struma ovarii with abdominal wall metastasis and cervical thyroid gland: a case report and review of the literature.

RET/PTC rearrangement in papillary thyroid carcinoma arising in malignant struma ovarii with abdominal wall metastasis and cervical thyroid gland: a case report and review of the literature.

RET/PTC rearrangement in papillary thyroid carcinoma arising in malignant struma ovarii with abdominal wall metastasis and cervical thyroid gland: a case report and review of the literature.

Background: Struma ovarii refers to rare mature cystic teratomas containing at least 50% of thyroid tissue, and malignant transformation is known to be even rarer. The synchronous development of malignant struma ovarii and cervical thyroid carcinoma are also scarce and poorly understood due to limited data about molecular features. Here, we present the first report of RET/PTC 1 rearrangement in synchronous metastatic malignant struma ovarii to the abdominal wall and cervical thyroid cancer.

Case presentation: We described a 47-year-old multigravida woman with bilateral adnexal and lower abdominal wall masses detected during the evaluation of abnormal uterine bleeding. The patient underwent a hysterectomy, bilateral salpingo-oophorectomy, and surgical removal of abdominal wall mass. Then, the pathological evaluation revealed papillary thyroid carcinoma (PTC) within struma ovarii and metastatic PTC in the abdominal wall fibro adipose tissue. Further, cervical thyroid gland physical examination and ultrasound illustrated a nodule within the left lobe. Subsequently, a total thyroidectomy was performed, and a histological examination revealed PTC. Furthermore, all affected tissue, i.e., struma ovarii, abdominal wall metastasis, and cervical thyroid gland tested for BRAF and RAS mutations and RET/PTC 1 rearrangement. RET/PTC 1 rearrangement was identified among all three different sites. Finally, after six years of follow-up, the patient had no evidence of recurrence or distant metastasis.

Conclusions: In light of these findings, malignant struma ovarii might yield a clue to cervical thyroid carcinoma, and the molecular analysis could provide valuable information for understanding the underlying mechanism, tumor clinicopathological behaviors, and prognosis.

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来源期刊
Thyroid Research
Thyroid Research Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
3.10
自引率
4.50%
发文量
21
审稿时长
8 weeks
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