在有轻度颅脑损伤史和创伤后应激障碍症状的军事APOE-4携带者中,花生四烯酸衍生的氧化脂质和Anandamide水平升高。

IF 1.8 Q3 CLINICAL NEUROLOGY
Neurotrauma reports Pub Date : 2023-09-25 eCollection Date: 2023-01-01 DOI:10.1089/neur.2023.0045
Aurore Nkiliza, Claire J C Huguenard, Gregory J Aldrich, Scott Ferguson, Adam Cseresznye, Teresa Darcey, James E Evans, Michael Dretsch, Michael Mullan, Fiona Crawford, Laila Abdullah
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引用次数: 0

摘要

目前批准的血液生物标志物可检测轻度至中度创伤性脑损伤(TBI)成年患者急性损伤后的颅内病变。然而,血液生物标志物仍然需要帮助在慢性损伤后时间点对轻度TBI(mTBI)和创伤后应激障碍(PTSD)进行鉴别诊断。由于磷脂(PL)功能障碍与创伤性脑损伤的慢性后果之间的联系,我们假设检查具有生物活性的PL代谢产物(氧基地平和乙醇酰胺)将有助于确定与mTBI和PTSD相关的长期脂质变化。伊拉克/阿富汗战争现役士兵血浆脂质提取物(对照 = 52,mTBI = 21,PTSD = 34和TBI+PPTSD = 13) 对其进行液相色谱/质谱分析以检测氧基化物和乙醇酰胺。进行线性回归分析,然后进行事后比较,以评估这些脂质与诊断分类的相关性。在对照组和mTBI、PTSD和mTBI+PPTSD组之间,发现源自花生四烯酸(AA)的oxylipins存在显著差异。在携带载脂蛋白E E4等位基因的mTBI+TPTSD患者中,通过细胞色素P450途径和阿那达明的AA衍生的氧基化蛋白水平显著升高。这些研究表明,AA衍生的oxylipins和anandamide可能是PTSD和mTBI+PPTSD的独特血液生物标志物。此外,这些AA代谢产物可能表明潜在的炎症过程,需要进一步研究。未来需要在更大的队列中进行验证研究,以确定该方法在临床环境中提供mTBI和PTSD鉴别诊断的潜在应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Levels of Arachidonic Acid-Derived Oxylipins and Anandamide Are Elevated Among Military <i>APOE</i> ɛ4 Carriers With a History of Mild Traumatic Brain Injury and Post-Traumatic Stress Disorder Symptoms.

Levels of Arachidonic Acid-Derived Oxylipins and Anandamide Are Elevated Among Military <i>APOE</i> ɛ4 Carriers With a History of Mild Traumatic Brain Injury and Post-Traumatic Stress Disorder Symptoms.

Levels of Arachidonic Acid-Derived Oxylipins and Anandamide Are Elevated Among Military <i>APOE</i> ɛ4 Carriers With a History of Mild Traumatic Brain Injury and Post-Traumatic Stress Disorder Symptoms.

Levels of Arachidonic Acid-Derived Oxylipins and Anandamide Are Elevated Among Military APOE ɛ4 Carriers With a History of Mild Traumatic Brain Injury and Post-Traumatic Stress Disorder Symptoms.

Currently approved blood biomarkers detect intracranial lesions in adult patients with mild to moderate traumatic brain injury (TBI) acutely post-injury. However, blood biomarkers are still needed to help with a differential diagnosis of mild TBI (mTBI) and post-traumatic stress disorder (PTSD) at chronic post-injury time points. Owing to the association between phospholipid (PL) dysfunction and chronic consequences of TBI, we hypothesized that examining bioactive PL metabolites (oxylipins and ethanolamides) would help identify long-term lipid changes associated with mTBI and PTSD. Lipid extracts of plasma from active-duty soldiers deployed to the Iraq/Afghanistan wars (control = 52, mTBI = 21, PTSD = 34, and TBI + PTSD = 13) were subjected to liquid chromatography/mass spectrometry analysis to examine oxylipins and ethanolamides. Linear regression analyses followed by post hoc comparisons were performed to assess the association of these lipids with diagnostic classifications. Significant differences were found in oxylipins derived from arachidonic acid (AA) between controls and mTBI, PTSD, and mTBI + PTSD groups. Levels of AA-derived oxylipins through the cytochrome P450 pathways and anandamide were significantly elevated among mTBI + PTSD patients who were carriers of the apolipoprotein E E4 allele. These studies demonstrate that AA-derived oxylipins and anandamide may be unique blood biomarkers of PTSD and mTBI + PTSD. Further, these AA metabolites may be indicative of an underlying inflammatory process that warrants further investigation. Future validation studies in larger cohorts are required to determine a potential application of this approach in providing a differential diagnosis of mTBI and PTSD in a clinical setting.

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CiteScore
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