long新冠肺炎持续多久?前瞻性队列研究中12至18个月的症状改善。

IF 1.4 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL
Robert M Barker-Davies, O O'Sullivan, D A Holdsworth, P Ladlow, A Houston, R Chamley, A Greenhalgh, E D Nicol, A N Bennett
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引用次数: 0

摘要

简介:在一定比例的患者中,新冠肺炎感染可导致长期综合征,包括疲劳、运动不耐受、情绪和认知问题。本研究旨在描述与对照组相比,COVID-19暴露组的疲劳相关、运动相关、情绪相关和认知相关结果。方法:113名现役英国武装部队参与者在5岁、12岁(n=88)和18岁时进行随访 新冠肺炎后数月(n=70)。18岁 月,56例为新冠肺炎暴露组,14例为匹配对照组。暴露的参与者包括住院(n=25)和社区(n=31)管理的参与者。43描述了5岁时六种最常见症状中的至少一种 几个月:疲劳、呼吸急促、胸痛、关节疼痛、运动不耐受和嗅觉缺失。参与者完成了症状清单、患者报告结果测量(PROM)、国家卫生研究所认知电池和6分钟步行测试(6MWT)。PROM包括疲劳评估量表(FAS)、全身性焦虑障碍-7(GAD-7)、患者健康问卷-9(PHQ-9)和创伤后应激患者检查表-5(PCL-5)。结果:5岁和12岁 月,暴露参与者的PHQ-9、PCL-5和FAS评分高于对照组(ES(效应大小)≥0.25,p≤0.04) 月,GAD-7与对照组无显著差异(ES p2≥0.126,第20.15页) 与匹配的对照组相比,暴露于新冠肺炎的参与者的病情有所改善,但在18个月的随访中有所改善。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
How long is Long-COVID? Symptomatic improvement between 12 and 18 months in a prospective cohort study.

Introduction: COVID-19 infection can precede, in a proportion of patients, a prolonged syndrome including fatigue, exercise intolerance, mood and cognitive problems. This study aimed to describe the profile of fatigue-related, exercise-related, mood-related and cognitive-related outcomes in a COVID-19-exposed group compared with controls.

Methods: 113 serving UK Armed Forces participants were followed up at 5, 12 (n=88) and 18 months (n=70) following COVID-19. At 18 months, 56 were in the COVID-19-exposed group with 14 matched controls. Exposed participants included hospitalised (n=25) and community (n=31) managed participants. 43 described at least one of the six most frequent symptoms at 5 months: fatigue, shortness of breath, chest pain, joint pain, exercise intolerance and anosmia. Participants completed a symptom checklist, patient-reported outcome measures (PROMs), the National Institute for Health cognitive battery and a 6-minute walk test (6MWT). PROMs included the Fatigue Assessment Scale (FAS), Generalised Anxiety Disorder-7 (GAD-7), Patient Health Questionnaire-9 (PHQ-9) and Patient Checklist-5 (PCL-5) for post-traumatic stress.

Results: At 5 and 12 months, exposed participants presented with higher PHQ-9, PCL-5 and FAS scores than controls (ES (effect size) ≥0.25, p≤0.04). By 12 months, GAD-7 was not significantly different to controls (ES <0.13, p=0.292). Remaining PROMs lost significant difference by 18 months (ES ≤0.11, p≥0.28). No significant differences in the cognitive scales were observed at any time point (F=1.96, p=0.167). At 5 and 12 months, exposed participants recorded significantly lower distances on the 6MWT (ηp 2≥0.126, p<0.01). 6MWT distance lost significant difference by 18 months (ηp 2<0.039, p>0.15).

Conclusions: This prospective cohort-controlled study observed adverse outcomes in depression, post-traumatic stress, fatigue and submaximal exercise performance up to 12 months but improved by 18-month follow-up, in participants exposed to COVID-19 compared with a matched control group.

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来源期刊
Bmj Military Health
Bmj Military Health MEDICINE, GENERAL & INTERNAL-
CiteScore
3.10
自引率
20.00%
发文量
116
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