腺苷A2A受体与胶质细胞。

International review of neurobiology Pub Date : 2023-01-01 Epub Date: 2023-09-07 DOI:10.1016/bs.irn.2023.08.002

Zhihua Gao

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引用次数: 1

摘要

腺苷A2A受体（A2AR）在大脑中大量表达，包括神经元和神经胶质细胞。虽然A2AR在神经胶质中的表达相对较低，但在病理条件下，其在星形胶质细胞和小胶质细胞中的水平显著升高。A2AR升高似乎在许多疾病状态中发挥着有害作用，通过促进神经炎症和星形细胞反应，导致神经退行性疾病和精神疾病的进展。

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Adenosine A_2A receptor and glia.

The adenosine A_2A receptor (A_2AR) is abundantly expressed in the brain, including both neurons and glial cells. While the expression of A_2AR is relative low in glia, its levels elevate robustly in astrocytes and microglia under pathological conditions. Elevated A_2AR appears to play a detrimental role in a number of disease states, by promoting neuroinflammation and astrocytic reaction to contribute to the progression of neurodegenerative and psychiatric diseases.

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International review of neurobiology

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