HLA同种免疫引起的血小板输注难治性：机制和管理的演变范式。

IF 6.9 2区医学 Q1 HEMATOLOGY

Blood Reviews Pub Date : 2023-11-01 DOI:10.1016/j.blre.2023.101135

Sandhya R. Panch , Li Guo , Ralph Vassallo

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引用次数: 0

摘要

HLA同种免疫引起的血小板输注难治性是一个重大的医学问题，尤其是在血液系统恶性肿瘤的多次输注患者和接受造血干细胞移植的患者中。HLA相容性血小板输注也给这些患者带来了巨大的经济负担。近年来，在HLA同种异体免疫和血小板输注难治性的发展中，已经描述了几种新的机制。我们回顾了血小板输注的历史以及HLA致敏和输注难治性的机制。我们还总结了HLA同种免疫引起的血小板输注难治性的诊断和治疗进展。

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Platelet transfusion refractoriness due to HLA alloimmunization: Evolving paradigms in mechanisms and management

Platelet transfusion refractoriness due to HLA alloimmunization presents a significant medical problem, particularly among multiply transfused patients with hematologic malignancies and those undergoing hematopoietic stem cell transplants. HLA compatible platelet transfusions also impose significant financial burden on these patients. Recently, several novel mechanisms have been described in the development of HLA alloimmunization and platelet transfusion refractoriness. We review the history of platelet transfusions and mechanisms of HLA-sensitization and transfusion refractoriness. We also summarize advances in the diagnosis and treatment of platelet transfusion refractoriness due to HLA alloimmunization.

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来源期刊

Blood Reviews 医学-血液学

CiteScore

13.80

自引率

1.40%

发文量

期刊介绍： Blood Reviews, a highly regarded international journal, serves as a vital information hub, offering comprehensive evaluations of clinical practices and research insights from esteemed experts. Specially commissioned, peer-reviewed articles authored by leading researchers and practitioners ensure extensive global coverage across all sub-specialties of hematology.