Susannah Pick, L S Merritt Millman, Yiqing Sun, Eleanor Short, Biba Stanton, Joel S Winston, Mitul A Mehta, Timothy R Nicholson, Antje A T S Reinders, Anthony S David, Mark J Edwards, Laura H Goldstein, Matthew Hotopf, Trudie Chalder
{"title":"功能性运动症状和功能性癫痫的客观和主观神经认知功能：初步发现。","authors":"Susannah Pick, L S Merritt Millman, Yiqing Sun, Eleanor Short, Biba Stanton, Joel S Winston, Mitul A Mehta, Timothy R Nicholson, Antje A T S Reinders, Anthony S David, Mark J Edwards, Laura H Goldstein, Matthew Hotopf, Trudie Chalder","doi":"10.1080/13803395.2023.2245110","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to provide a preliminary assessment of objective and subjective neurocognitive functioning in individuals with functional motor symptoms (FMS) and/or functional seizures (FS). We tested the hypotheses that the FMS/FS group would display poorer objective attentional and executive functioning, altered social cognition, and reduced metacognitive accuracy.</p><p><strong>Method: </strong>Individuals with FMS/FS (n = 16) and healthy controls (HCs, n = 17) completed an abbreviated CANTAB battery, and measures of intellectual functioning, subjective cognitive complaints, performance validity, and comorbid symptoms. Subjective performance ratings were obtained to assess local metacognitive accuracy.</p><p><strong>Results: </strong>The groups were comparable in age (p = 0.45), sex (p = 0.62), IQ (p = 0.57), and performance validity (p-values = 0.10-0.91). We observed no impairment on any CANTAB test in this FMS/FS sample compared to HCs, although the FMS/FS group displayed shorter reaction times on the Emotional Bias task (anger) (p = 0.01, np2 = 0.20). The groups did not differ in subjective performance ratings (p-values 0.15). Whilst CANTAB attentional set-shifting performance (total trials/errors) correlated with subjective performance ratings in HCs (p-values<0.005, r<sub>s</sub> = -0.85), these correlations were non-significant in the FMS/FS sample (p-values = 0.10-0.13, r<sub>s</sub>-values = -0.46-0.50). The FMS/FS group reported more daily cognitive complaints than HCs (p = 0.006, g = 0.92), which were associated with subjective performance ratings on CANTAB sustained attention (p = 0.001, r<sub>s</sub> = -0.74) and working memory tests (p < 0.001, r<sub>s</sub> = -0.75), and with depression (p = 0.003, r<sub>s</sub> = 0.70), and somatoform (p = 0.003, r<sub>s</sub> = 0.70) and psychological dissociation (p-values<0.005, r<sub>s</sub>-values = 0.67-0.85).</p><p><strong>Conclusions: </strong>These results suggest a discordance between objective and subjective neurocognitive functioning in this FMS/FS sample, reflecting intact test performance alongside poorer subjective cognitive functioning. Further investigation of neurocognitive functioning in FND subgroups is necessary.</p>","PeriodicalId":15382,"journal":{"name":"Journal of clinical and experimental neuropsychology","volume":null,"pages":null},"PeriodicalIF":1.8000,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11057846/pdf/","citationCount":"0","resultStr":"{\"title\":\"Objective and subjective neurocognitive functioning in functional motor symptoms and functional seizures: preliminary findings.\",\"authors\":\"Susannah Pick, L S Merritt Millman, Yiqing Sun, Eleanor Short, Biba Stanton, Joel S Winston, Mitul A Mehta, Timothy R Nicholson, Antje A T S Reinders, Anthony S David, Mark J Edwards, Laura H Goldstein, Matthew Hotopf, Trudie Chalder\",\"doi\":\"10.1080/13803395.2023.2245110\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>This study aimed to provide a preliminary assessment of objective and subjective neurocognitive functioning in individuals with functional motor symptoms (FMS) and/or functional seizures (FS). We tested the hypotheses that the FMS/FS group would display poorer objective attentional and executive functioning, altered social cognition, and reduced metacognitive accuracy.</p><p><strong>Method: </strong>Individuals with FMS/FS (n = 16) and healthy controls (HCs, n = 17) completed an abbreviated CANTAB battery, and measures of intellectual functioning, subjective cognitive complaints, performance validity, and comorbid symptoms. Subjective performance ratings were obtained to assess local metacognitive accuracy.</p><p><strong>Results: </strong>The groups were comparable in age (p = 0.45), sex (p = 0.62), IQ (p = 0.57), and performance validity (p-values = 0.10-0.91). We observed no impairment on any CANTAB test in this FMS/FS sample compared to HCs, although the FMS/FS group displayed shorter reaction times on the Emotional Bias task (anger) (p = 0.01, np2 = 0.20). The groups did not differ in subjective performance ratings (p-values 0.15). Whilst CANTAB attentional set-shifting performance (total trials/errors) correlated with subjective performance ratings in HCs (p-values<0.005, r<sub>s</sub> = -0.85), these correlations were non-significant in the FMS/FS sample (p-values = 0.10-0.13, r<sub>s</sub>-values = -0.46-0.50). The FMS/FS group reported more daily cognitive complaints than HCs (p = 0.006, g = 0.92), which were associated with subjective performance ratings on CANTAB sustained attention (p = 0.001, r<sub>s</sub> = -0.74) and working memory tests (p < 0.001, r<sub>s</sub> = -0.75), and with depression (p = 0.003, r<sub>s</sub> = 0.70), and somatoform (p = 0.003, r<sub>s</sub> = 0.70) and psychological dissociation (p-values<0.005, r<sub>s</sub>-values = 0.67-0.85).</p><p><strong>Conclusions: </strong>These results suggest a discordance between objective and subjective neurocognitive functioning in this FMS/FS sample, reflecting intact test performance alongside poorer subjective cognitive functioning. 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Objective and subjective neurocognitive functioning in functional motor symptoms and functional seizures: preliminary findings.
Introduction: This study aimed to provide a preliminary assessment of objective and subjective neurocognitive functioning in individuals with functional motor symptoms (FMS) and/or functional seizures (FS). We tested the hypotheses that the FMS/FS group would display poorer objective attentional and executive functioning, altered social cognition, and reduced metacognitive accuracy.
Method: Individuals with FMS/FS (n = 16) and healthy controls (HCs, n = 17) completed an abbreviated CANTAB battery, and measures of intellectual functioning, subjective cognitive complaints, performance validity, and comorbid symptoms. Subjective performance ratings were obtained to assess local metacognitive accuracy.
Results: The groups were comparable in age (p = 0.45), sex (p = 0.62), IQ (p = 0.57), and performance validity (p-values = 0.10-0.91). We observed no impairment on any CANTAB test in this FMS/FS sample compared to HCs, although the FMS/FS group displayed shorter reaction times on the Emotional Bias task (anger) (p = 0.01, np2 = 0.20). The groups did not differ in subjective performance ratings (p-values 0.15). Whilst CANTAB attentional set-shifting performance (total trials/errors) correlated with subjective performance ratings in HCs (p-values<0.005, rs = -0.85), these correlations were non-significant in the FMS/FS sample (p-values = 0.10-0.13, rs-values = -0.46-0.50). The FMS/FS group reported more daily cognitive complaints than HCs (p = 0.006, g = 0.92), which were associated with subjective performance ratings on CANTAB sustained attention (p = 0.001, rs = -0.74) and working memory tests (p < 0.001, rs = -0.75), and with depression (p = 0.003, rs = 0.70), and somatoform (p = 0.003, rs = 0.70) and psychological dissociation (p-values<0.005, rs-values = 0.67-0.85).
Conclusions: These results suggest a discordance between objective and subjective neurocognitive functioning in this FMS/FS sample, reflecting intact test performance alongside poorer subjective cognitive functioning. Further investigation of neurocognitive functioning in FND subgroups is necessary.
期刊介绍：
Journal of Clinical and Experimental Neuropsychology ( JCEN) publishes research on the neuropsychological consequences of brain disease, disorders, and dysfunction, and aims to promote the integration of theories, methods, and research findings in clinical and experimental neuropsychology. The primary emphasis of JCEN is to publish original empirical research pertaining to brain-behavior relationships and neuropsychological manifestations of brain disease. Theoretical and methodological papers, critical reviews of content areas, and theoretically-relevant case studies are also welcome.
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