宫颈鳞状上皮内病变的临床和形态学研究。

Current health sciences journal Pub Date : 2023-04-01 Epub Date: 2023-06-30 DOI:10.12865/CHSJ.49.02.220
Larisa Iovan, Ilona Mihaela Liliac, Anca-Maria Istrate-Ofiteru, Camelia-Gabriela Rosu, Laurentiu Mogoanta
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引用次数: 0

摘要

鳞状上皮内病变(SILs)是癌症前体,是癌症二级预防计划的目标,有时难以准确分级。Mena是一种肌动蛋白调节蛋白,参与细胞膜突起、细胞运动、肿瘤侵袭和转移。我们回顾性研究了68例被诊断为鳞状上皮内病变的患者,这些患者接受了快速治疗(未经阴道镜活检的治疗)。我们分析了患者病历中的人口统计学、行为学数据、产科和病史,并研究了切除手术后采集的宫颈碎片或视锥。我们的研究未能确定SILs与风险因素之间的相关性,如低社会经济地位、联合口服避孕药的使用、宫内节育器的使用、产次、重力,但吸烟习惯被证明与宫颈病变的发展有关。Mena在大多数分析的SIL中表达,其表达与病变的面积和强度相关,这表明Mena对异常细胞的染色尤其明显,其表达强度与恶性转化的风险相关。需要进一步的研究来验证Mena是宫颈癌发生的早期标志物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Clinical and Morphological Study of Cervical Squamous Intraepithelial Lesions.

Clinical and Morphological Study of Cervical Squamous Intraepithelial Lesions.

Clinical and Morphological Study of Cervical Squamous Intraepithelial Lesions.

Clinical and Morphological Study of Cervical Squamous Intraepithelial Lesions.

Squamous intraepithelial lesions (SILs) are cancer precursors targeted by secondary prevention of cervical cancer programs that are sometimes difficult to grade accurately. Mena is an actin regulatory protein involved in membrane protrusion, cell motility, in tumor invasion and metastasis. We studied retrospectively 68 cases of patients diagnosed with squamous intraepithelial lesions that received expedited treatment (treatment without colposcopic biopsy). We analyzed demographic, behavioral data, obstetrical and medical history, from the patients' medical charts and we studied the cervical fragments or cones harvested after the excisional procedure. Our study failed to identify a correlation between SILs and risk factors such as low socioeconomic status, combined oral contraceptive use, intrauterine device use, parity, gravity, except for the tobacco smoking habit that proved to be related to the cervical lesions' development. Mena was expressed in most of the analyzed SILs and its expression was correlated with lesions' grade in terms of both area and intensity, suggesting that Mena stains especially abnormal cells and that its expression intensity correlates with the risk of malignant transformation. Further studies are needed to validate Mena as an early stage of cervical carcinogenesis marker.

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