在雌性小鼠中选择性地繁殖高自主性体力活动并不能赋予类似心脏偏心重塑的固有特征,但小肌肉表型确实具有。

IF 2.3 Q2 SPORT SCIENCES
Eric C. Leszczynski , Nicole E. Schwartz , Ashley C. McPeek , Katharine D. Currie , David P. Ferguson , Theodore Garland Jr.
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引用次数: 0

摘要

参与体育活动会带来各种积极的健康结果,包括部分由于心脏偏心重塑而降低心血管疾病风险。这项研究的目的是确定四个被选择性培育用于车轮上自愿运动的HighRunner小鼠复制系是否具有类似于偏心重塑结果的心脏表型。来自4个High Runner和4个未选择的对照品系的成年雌性(平均年龄55天)通过汽化异氟烷麻醉,然后收集超声心动图图像并分析其结构和功能差异。与对照小鼠系相比,HighRunner小鼠的射血分数通常较低(双尾p​=​0.0236),并且倾向于左心室前部的壁较厚(p​=​0.065)。然而,一组被称为迷你肌肉小鼠的高跑者个体的射血分数更高(p​=​0.0006),分数缩短百分比(p​p​V*O2最大值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Selectively breeding for high voluntary physical activity in female mice does not bestow inherent characteristics that resemble eccentric remodeling of the heart, but the mini-muscle phenotype does

Selectively breeding for high voluntary physical activity in female mice does not bestow inherent characteristics that resemble eccentric remodeling of the heart, but the mini-muscle phenotype does

Selectively breeding for high voluntary physical activity in female mice does not bestow inherent characteristics that resemble eccentric remodeling of the heart, but the mini-muscle phenotype does

Selectively breeding for high voluntary physical activity in female mice does not bestow inherent characteristics that resemble eccentric remodeling of the heart, but the mini-muscle phenotype does

Physical activity engagement results in a variety of positive health outcomes, including a reduction in cardiovascular disease risk partially due to eccentric remodeling of the heart. The purpose of this investigation was to determine if four replicate lines of High Runner mice that have been selectively bred for voluntary exercise on wheels have a cardiac phenotype that resembles the outcome of eccentric remodeling. Adult females (average age 55 days) from the 4 High Runner and 4 non-selected control lines were anaesthetized via vaporized isoflurane, then echocardiographic images were collected and analyzed for structural and functional differences. High Runner mice in general had lower ejection fractions compared to control mice lines (2-tailed p ​= ​0.023 6) and tended to have thicker walls of the anterior portion of the left ventricle (p ​= ​0.065). However, a subset of the High Runner individuals, termed mini-muscle mice, had greater ejection fraction (p ​= ​0.000 6), fractional shortening percentage (p ​< ​0.000 1), and ventricular mass at dissection (p ​< ​0.002 7 with body mass as a covariate) compared to non-mini muscle mice. Mice from replicate lines bred for high voluntary exercise did not all have inherent positive cardiac functional or structural characteristics, although a genetically unique subset of mini-muscle individuals did have greater functional cardiac characteristics, which in conjunction with their previously described peripheral aerobic enhancements (e.g., increased capillarity) would partially account for their increased V˙ O2max.

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来源期刊
Sports Medicine and Health Science
Sports Medicine and Health Science Health Professions-Physical Therapy, Sports Therapy and Rehabilitation
CiteScore
5.50
自引率
0.00%
发文量
36
审稿时长
55 days
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