儿童缺铁性贫血胃肠道病变的内镜检查结果和预测因素。

IF 1.2 4区 医学 Q4 HEMATOLOGY
Pediatric Hematology and Oncology Pub Date : 2024-01-01 Epub Date: 2024-02-10 DOI:10.1080/08880018.2023.2261986
Hyun Jin Kim, Yeon Jung Lim
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引用次数: 0

摘要

缺铁性贫血(IDA)可由隐性胃肠道(GI)失血引起;然而,儿童贫血的内镜检查结果尚不清楚。本研究旨在确定接受内窥镜检查的IDA儿童病变的频率和相关因素。我们回顾性分析了实验室诊断为IDA的儿童的临床和内镜检查结果。在58名患者中,36名(62.1%)有上消化道病变,其中侵蚀性胃炎是最常见的病变。此外,26名患者同时接受了结肠镜检查,12名(46.2%)患者有下消化道病变。总的来说,44名(75.9%)患者的上消化道或下消化道有病变。13名患者(22.4%)检测到幽门螺杆菌感染。内镜检查发现病变的患者血红蛋白水平显著降低(8.9vs.10.0 g/dL,p = 0.047)和平均红细胞体积(75.5对80.9 fL,p = 0.038)。既往接受IDA治疗的患者比例也高于内窥镜检查中有病变的患者。在多变量分析中,年龄≥10岁 年(比值比[OR],6.00;95%置信区间[CI],0.56-10.75)和粪便潜血试验(FOBT)阳性结果(OR,2.25;95%CI,0.14-4.52)是与胃肠道病变相关的因素。胃肠道症状的存在与胃肠道病变无关。在本研究中,内窥镜检查发现IDA儿童的胃肠道病变比例较高。即使没有胃肠道症状,IDA儿童也应考虑内镜检查,尤其是年龄较大的儿童和FOBT结果呈阳性的儿童。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Endoscopic findings and predictors of gastrointestinal lesions in children with iron deficiency anemia.

Iron deficiency anemia (IDA) can be caused by occult gastrointestinal (GI) blood loss; however, the endoscopic findings in children with anemia are unclear. The study aimed to determine the frequency and factors related to lesions in children with IDA undergoing endoscopy. We retrospectively analyzed the clinical and endoscopic findings of children with a laboratory-based diagnosis of IDA. Of 58 patients, 36 (62.1%) had upper GI tract lesions, with erosive gastritis being the most common lesion. Further, 26 patients underwent concomitant colonoscopy, and 12 (46.2%) had lower GI tract lesions. Overall, 44 (75.9%) patients had lesions in either the upper or lower GI tract. Helicobacter pylori infection was detected in 13 patients (22.4%). Patients with lesions found by endoscopy had significantly lower hemoglobin level (8.9 vs. 10.0 g/dL, p = 0.047) and mean corpuscular volume (75.5 vs. 80.9 fL, p = 0.038). The proportion of patients with previous treatment for IDA was also higher in those with lesions on endoscopy. In multivariate analysis, age of ≥10 years (odds ratio [OR], 6.00; 95% confidence Interval [CI], 0.56-10.75) and positive fecal occult blood test (FOBT) findings (OR, 2.25; 95% CI, 0.14-4.52) were factors related to GI lesions. The presence of GI symptoms was not associated with GI lesions. A high proportion of GI lesions were found by endoscopy in children with IDA in this study. Endoscopy should be considered in children with IDA even without GI symptoms, especially in older children, and those with positive FOBT results.

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来源期刊
CiteScore
2.60
自引率
5.90%
发文量
71
审稿时长
6-12 weeks
期刊介绍: PHO: Pediatric Hematology and Oncology covers all aspects of research and patient management within the area of blood disorders and malignant diseases of childhood. Our goal is to make PHO: Pediatric Hematology and Oncology the premier journal for the international community of clinicians and scientists who together aim to define optimal therapeutic strategies for children and young adults with cancer and blood disorders. The journal supports articles that address research in diverse clinical settings, exceptional case studies/series that add novel insights into pathogenesis and/or clinical care, and reviews highlighting discoveries and challenges emerging from consortia and conferences. Clinical studies as well as basic and translational research reports regarding cancer pathogenesis, genetics, molecular diagnostics, pharmacology, stem cells, molecular targeting, cellular and immune therapies and transplantation are of interest. Papers with a focus on supportive care, late effects and on related ethical, legal, psychological, social, cultural, or historical aspects of these fields are also appreciated. Reviews on important developments in the field are welcome. Articles from scientists and clinicians across the international community of Pediatric Hematology and Oncology are considered for publication. The journal is not dependent on or connected with any organization or society. All submissions undergo rigorous peer review prior to publication. Our Editorial Board includes experts in Pediatric Hematology and Oncology representing a wide range of academic and geographic diversity.
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