Jiang Hu , Guo-Fen Li , Feng-Ming Xu , Qiang Li , Tao Lv , Tian-Feng Peng , Si Yin , Wei Gong
{"title":"灵芝中的抗菌羊毛甾烷三萜类化合物。","authors":"Jiang Hu , Guo-Fen Li , Feng-Ming Xu , Qiang Li , Tao Lv , Tian-Feng Peng , Si Yin , Wei Gong","doi":"10.1080/10286020.2023.2260749","DOIUrl":null,"url":null,"abstract":"<div><p>A phytochemical investigation on the 80% EtOH extract of the fruiting bodies of <em>Ganoderma tsugae</em> resulted into the isolation of two previously undescribed lanostane triterpenoids, 7,11-dioxo-3<em>β</em>-acetyloxy-26,27-dihydroxy-lanosta-8,24-diene (<strong>1</strong>) and 7,20-dioxo-3<em>β</em>-acetyloxy-11<em>β,</em>15<em>α</em>-dihydroxy-22,23,24,25,26,27-hexanorlanosta-8-ene (<strong>2</strong>), togeher with one known lanostane triterpenoid ganodermanontriol (<strong>3</strong>). Structural elucidation of all the compounds were performed by spectral methods such as 1D and 2D (<sup>1</sup>H<em>-</em><sup>1</sup>H COSY, HMQC, and HMBC) NMR spectroscopy. All the triterpenoids were <em>in vitro</em> evaluated for their antibacterial activities against six pathogenic microorganisms. Compound <strong>3</strong> exhibited some activities against three Gram positive bacteria with MIC values less than 30 μg/ml.</p></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3000,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Antibacterial lanostane triterpenoids from Ganoderma tsugae\",\"authors\":\"Jiang Hu , Guo-Fen Li , Feng-Ming Xu , Qiang Li , Tao Lv , Tian-Feng Peng , Si Yin , Wei Gong\",\"doi\":\"10.1080/10286020.2023.2260749\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>A phytochemical investigation on the 80% EtOH extract of the fruiting bodies of <em>Ganoderma tsugae</em> resulted into the isolation of two previously undescribed lanostane triterpenoids, 7,11-dioxo-3<em>β</em>-acetyloxy-26,27-dihydroxy-lanosta-8,24-diene (<strong>1</strong>) and 7,20-dioxo-3<em>β</em>-acetyloxy-11<em>β,</em>15<em>α</em>-dihydroxy-22,23,24,25,26,27-hexanorlanosta-8-ene (<strong>2</strong>), togeher with one known lanostane triterpenoid ganodermanontriol (<strong>3</strong>). Structural elucidation of all the compounds were performed by spectral methods such as 1D and 2D (<sup>1</sup>H<em>-</em><sup>1</sup>H COSY, HMQC, and HMBC) NMR spectroscopy. All the triterpenoids were <em>in vitro</em> evaluated for their antibacterial activities against six pathogenic microorganisms. Compound <strong>3</strong> exhibited some activities against three Gram positive bacteria with MIC values less than 30 μg/ml.</p></div>\",\"PeriodicalId\":15180,\"journal\":{\"name\":\"Journal of Asian Natural Products Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2024-05-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Asian Natural Products Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/org/science/article/pii/S102860202300245X\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Asian Natural Products Research","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S102860202300245X","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
Antibacterial lanostane triterpenoids from Ganoderma tsugae
A phytochemical investigation on the 80% EtOH extract of the fruiting bodies of Ganoderma tsugae resulted into the isolation of two previously undescribed lanostane triterpenoids, 7,11-dioxo-3β-acetyloxy-26,27-dihydroxy-lanosta-8,24-diene (1) and 7,20-dioxo-3β-acetyloxy-11β,15α-dihydroxy-22,23,24,25,26,27-hexanorlanosta-8-ene (2), togeher with one known lanostane triterpenoid ganodermanontriol (3). Structural elucidation of all the compounds were performed by spectral methods such as 1D and 2D (1H-1H COSY, HMQC, and HMBC) NMR spectroscopy. All the triterpenoids were in vitro evaluated for their antibacterial activities against six pathogenic microorganisms. Compound 3 exhibited some activities against three Gram positive bacteria with MIC values less than 30 μg/ml.
期刊介绍：
The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures.
All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.
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