Mario Amore Cecchini, Mario A Parra, Miriam Brazzelli, Robert H Logie, Sergio Della Sala
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The objective of the present study was to conduct a meta-analysis of results from STM binding tests used in the assessment of samples mapped along the AD clinical continuum.</p><p><strong>Method: </strong>We searched PubMed, Scopus, and Web of Science for articles that assessed patients with AD (from preclinical to dementia) using the STM binding tests and compared their results with those of controls. From each relevant article, we extracted the number of participants, the mean and standard deviations from single feature and of feature binding conditions. Results across studies were combined using standardized mean differences (effect sizes) to produce overall estimates of effect.</p><p><strong>Results: </strong>The feature binding condition of the STM binding showed large effects in all stages of AD. However, small sample sizes across studies, the presence of moderate to high heterogeneity and cross-sectional, case-controls designs decreased our confidence in the current evidence.</p><p><strong>Conclusions: </strong>To be considered as a cognitive marker for AD, properly powered longitudinal designs and studies that clearly relate conjunctive memory tests with biomarkers (amyloid and tau) are still needed. (PsycInfo Database Record (c) 2023 APA, all rights reserved).</p>","PeriodicalId":19205,"journal":{"name":"Neuropsychology","volume":"37 7","pages":"769-789"},"PeriodicalIF":2.6000,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":"{\"title\":\"Short-term memory conjunctive binding in Alzheimer's disease: A systematic review and meta-analysis.\",\"authors\":\"Mario Amore Cecchini, Mario A Parra, Miriam Brazzelli, Robert H Logie, Sergio Della Sala\",\"doi\":\"10.1037/neu0000825\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>Short-term memory (STM) binding tests assess the ability to temporarily hold conjunctions between surface features, such as objects and their colors (i.e., feature binding condition), relative to the ability to hold the individual features (i.e., single feature condition). 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However, small sample sizes across studies, the presence of moderate to high heterogeneity and cross-sectional, case-controls designs decreased our confidence in the current evidence.</p><p><strong>Conclusions: </strong>To be considered as a cognitive marker for AD, properly powered longitudinal designs and studies that clearly relate conjunctive memory tests with biomarkers (amyloid and tau) are still needed. 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引用次数: 3
摘要
目的:短期记忆(STM)结合测试评估暂时保持物体及其颜色等表面特征之间连接的能力(即特征结合条件),相对于保持单个特征的能力(如单个特征条件)。这些测试的表现受损被认为是阿尔茨海默病(AD)的认知标志。本研究的目的是对用于评估AD临床连续体样本的STM结合测试结果进行荟萃分析。方法:我们在PubMed、Scopus和Web of Science上搜索使用STM结合测试评估AD患者(从临床前到痴呆)的文章,并将其结果与对照组进行比较。从每一篇相关文章中,我们提取了参与者的数量、单个特征和特征绑定条件的平均值和标准差。使用标准化平均差异(效应大小)将研究结果进行组合,以产生对效应的总体估计。结果:STM结合的特征结合条件在AD的所有阶段都显示出很大的影响。然而,研究中的小样本量、中高度异质性和横断面病例对照设计的存在降低了我们对当前证据的信心。结论:要被视为AD的认知标志物,仍然需要适当的纵向设计和研究,将结膜记忆测试与生物标志物(淀粉样蛋白和tau)清楚地联系起来。(PsycInfo数据库记录(c)2023 APA,保留所有权利)。
Short-term memory conjunctive binding in Alzheimer's disease: A systematic review and meta-analysis.
Objective: Short-term memory (STM) binding tests assess the ability to temporarily hold conjunctions between surface features, such as objects and their colors (i.e., feature binding condition), relative to the ability to hold the individual features (i.e., single feature condition). Impairments in performance of these tests have been considered cognitive markers of Alzheimer's disease (AD). The objective of the present study was to conduct a meta-analysis of results from STM binding tests used in the assessment of samples mapped along the AD clinical continuum.
Method: We searched PubMed, Scopus, and Web of Science for articles that assessed patients with AD (from preclinical to dementia) using the STM binding tests and compared their results with those of controls. From each relevant article, we extracted the number of participants, the mean and standard deviations from single feature and of feature binding conditions. Results across studies were combined using standardized mean differences (effect sizes) to produce overall estimates of effect.
Results: The feature binding condition of the STM binding showed large effects in all stages of AD. However, small sample sizes across studies, the presence of moderate to high heterogeneity and cross-sectional, case-controls designs decreased our confidence in the current evidence.
Conclusions: To be considered as a cognitive marker for AD, properly powered longitudinal designs and studies that clearly relate conjunctive memory tests with biomarkers (amyloid and tau) are still needed. (PsycInfo Database Record (c) 2023 APA, all rights reserved).
期刊介绍:
Neuropsychology publishes original, empirical research; systematic reviews and meta-analyses; and theoretical articles on the relation between brain and human cognitive, emotional, and behavioral function.