副蛋白-持久的生物标志物。

Q1 Biochemistry, Genetics and Molecular Biology

Clinical Biochemist Reviews Pub Date : 2019-02-01

Jillian R Tate

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引用次数: 0

摘要

“副蛋白”，也称为M蛋白、单克隆蛋白和单克隆成分，作为单克隆免疫球蛋白病的关键生物标志物，经受住了时间的考验。随着新的电泳和免疫分析方法的发展，它不断地自我改造，这些方法在分析上更敏感。特别是无血清轻链免疫测定法的使用，在诊断和监测浆细胞发育异常和其他单克隆gammopathies患者方面带来了新的临床发现和改进。此外，可以使用质谱和流式细胞术方法检测最小残留疾病。

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The Paraprotein - an Enduring Biomarker.

The 'paraprotein', also known as M-protein, monoclonal protein and monoclonal component, has stood the test of time as the key biomarker in monoclonal gammopathies. It continues to reinvent itself as new electrophoretic and immunoassay methods are developed that are analytically more sensitive. Use of the serum free light chain immunoassay in particular has led to new clinical discoveries and improvements in the diagnosis and monitoring of patients with plasma cell dyscrasia and other monoclonal gammopathies. In addition, minimal residual disease can be detected using mass spectrometry and flow cytometry methods.

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Clinical Biochemist Reviews Biochemistry, Genetics and Molecular Biology-Clinical Biochemistry

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