从海生真菌链格孢X112中分离得到一种新的蒽醌衍生物。

IF 1.9 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2025-01-01 Epub Date: 2023-09-21 DOI:10.1080/14786419.2023.2258540

Xiaoyuan Xu, Gang Li, Rao Fu, Hongxiang Lou, Xiaoping Peng

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引用次数: 0

摘要

从海鱼Gadus macronephalus中分离得到一种新的蒽醌类化合物Alterminacid A（1）和五种已知的衍生物，即粗基酸（2）、大黄素（3）、大蛋白（4）、phomarin（5）和1,7-二羟基-3-甲基蒽-9,10-二酮（6）。通过分析MS和NMR数据确定了它们的结构。评价了新化合物1的细胞毒性、抗肿瘤病原体活性、抗菌活性和群体感应抑制潜力。

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A new anthraquinone derivative from the marine fish-derived fungus Alternaria sp. X112.

A new anthraquinone, altermodinacid A (1), and five known derivatives, pachybasic acid (2), emodic acid (3), emodin (4), phomarin (5), and 1,7-dihydroxy-3-methylanthracene-9,10-dione (6), were discovered from a halotolerant fungus Alternaria sp. X112 isolated from a marine fish Gadus macrocephalus. Their structures were determined by analysing MS and NMR data. The cytotoxic effect, antiagricultural pathogens activity, antibacterial activity and quorum sensing inhibitory potential of new compound 1 were evaluated.

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.