人类肠道病毒D68感染的血清流行率:一项系统综述和荟萃分析。

IF 3.2 4区 医学 Q3 VIROLOGY
Intervirology Pub Date : 2023-01-01 Epub Date: 2023-10-04 DOI:10.1159/000531853
Yingying Shi, Qinqin Ran, Xiaochen Wang, Lu Shi
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引用次数: 0

摘要

简介:人类肠道病毒D68(EV-D68)属于小核糖核酸家族的肠道病毒,是一种可引起急性呼吸道感染和中枢神经系统疾病的肠道病毒。本研究系统分析和总结了数据库中的EV-D68抗体研究,并确定了不同地区、年龄和性别的血清阳性率。方法:采用STATA16.0软件进行荟萃分析。I2和Q检验用于分析纳入研究的异质性。对不同组进行荟萃回归分析,并使用Egger线性回归分析来评估发表偏倚。结果:多项研究结果表明,EV-D68抗体的血清学患病率范围为17.78%-96.69%。荟萃分析结果显示,EV-D68-抗体的血清阳性率为76%(95%CI:67%-84%),其中中国人群为74%(95%CI:61%-86%),其他国家为79%(95%CI:65%-91%)。同时,进行了亚组分析。EV-D68抗体的血清流行率与年龄有关,但与性别或地区无关。结论:5岁以下年龄组血清阳性率较低;然而,它随着年龄的增长而逐渐增加。本研究结果表明,EV-D68感染在人群中普遍存在,目前的临床感染情况无法反映该病毒的实际流行情况,其中5岁以下儿童易感染,应更加重视疫情防控。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Seroprevalence of Enterovirus D68 Infection among Humans: A Systematic Review and Meta-Analysis.

Seroprevalence of Enterovirus D68 Infection among Humans: A Systematic Review and Meta-Analysis.

Seroprevalence of Enterovirus D68 Infection among Humans: A Systematic Review and Meta-Analysis.

Seroprevalence of Enterovirus D68 Infection among Humans: A Systematic Review and Meta-Analysis.

Introduction: Human enterovirus D68 (EV-D68), which belongs to enteroviruses of the small RNA family, is a type of enterovirus that can cause acute respiratory tract infection and central nervous system diseases. This study systematically analysed and summarized EV-D68 antibody studies in databases and identified the seropositivity rates of different regions, ages, and sexes.

Methods: Meta-analysis was performed using STATA 16.0 software. I2 and Q tests were used to analyse the heterogeneity of the included studies. Meta-regression analysis was performed for different groups, and Egger's linear regression analysis was used to evaluate publication bias.

Results: The results of multiple studies indicated that the serological prevalence range of EV-D68 antibody was 17.78-96.69%. The results of the meta-analysis showed that the seropositivity rate of EV-D68 antibody was 76% (95% confidence interval [CI]: 67-84%), among which that of the Chinese population was 74% (95% CI: 61-86%) and that of other countries was 79% (95% CI: 65-91%). At the same time, a subgroup analysis was conducted. The seroprevalence of EV-D68 antibody was related to age but not sex or region.

Conclusion: The seropositivity rate was lower in the below 5-year age group; however, it gradually increased with age. The results of this study showed that EV-D68 infection was widespread in the population, and the current clinical infection situation could not reflect the actual epidemic situation of the virus, among which children under 5 years old were vulnerable to infection, which should be given greater attention for epidemic prevention and control.

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来源期刊
Intervirology
Intervirology 医学-病毒学
CiteScore
5.40
自引率
0.00%
发文量
13
审稿时长
6-12 weeks
期刊介绍: ''Intervirology'' covers progress in both basic and clinical virus research, and aims to provide a forum for the various disciplines within virology. Issues publishing original papers alternate with thematic issues, focusing on clearly defined topics. This thematic concentration serves to make timely reviews, research reports and controversy easily accessible to both specialists in the field and those who want to keep track of the latest developments outside their own area of interest. In addition to original papers, regular issues publish short communications and letters to the editor to provide readers with a forum for the exchange of ideas and comments. The scope encompasses work on the molecular biology of human and animal viruses, including genome organization and regulation, and the structure and function of viral proteins. The pathogenesis, immunology, diagnosis, epidemiology, prophylaxis and therapy of viral diseases are considered.
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