激光诱导间质热疗对脑三维肿瘤的治疗建模。

IF 1.4 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Journal of lasers in medical sciences Pub Date : 2023-08-22 eCollection Date: 2023-01-01 DOI:10.34172/jlms.2023.26
Sadegh Amini, Hossein Ahmadikia
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引用次数: 0

摘要

引言:有一些方法可以检测肿瘤组织中的热传递,这是生物工程中的一个重要问题。其中一种方法是在连续介质中使用Pennes提出的生物热方程。另一种是使用多孔介质来模拟活体组织中的热传递。本文的目的是研究一种模拟脑组织中温度分布和肿瘤消融的方法,并将结果与Pennes的方法进行比较。方法:这种方法提出并使用多孔介质代替连续介质作为组织。此外,在温度模拟和细胞消融量方面对两种方法(在连续介质和多孔介质中模拟)进行了比较。密度、热传导因子和血液灌注速率被认为是温度的函数。结果:在这些方法中,经过85秒的治疗后,温度升高至约90°C。多孔介质的温度升高与连续介质的温度增加相对相同,因此,在多孔介质中消融的癌细胞的量与在连续介质中大致相同。对于两种想法,细胞消融的体积约为6500mm3。此外,根据阿伦尼斯积分法计算的损伤程度和肿瘤消融体积在治疗结束时是相等的。根据结果,与连续方法类似,多孔方法可以预测受损细胞的温度和体积。结论:因此,使用多孔入路代替Pennes入路治疗肿瘤是可能的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Treatment Modelling of a 3D Tumour in Brain by Laser-Induced Interstitial Thermotherapy.

Introduction: There are some ways to examine heat transfer in tumor tissue, which is an important issue in bioengineering. One of these ways uses the bioheat equation, proposed by Pennes, in a continuous medium. Another one uses a porous medium to model heat transfer in living tissues. The objective of this paper was to study an approach to modelling the temperature distribution and tumour ablation in brain tissue and compare results to Pennes' approach. Methods: This approach presents and uses a porous medium as the tissue instead of a continuous medium. In addition, the two approaches (simulation in continuous and porous medium) are compared in terms of temperature simulation and amount of cell ablation. The density, heat conduction factor, and blood perfusion rate are considered functions of temperature. Results: In these approaches, after an 85-second treatment, the temperature increases to about 90°C. The temperature increase of the porous medium is relatively the same as that of the continuous medium and for this reason, the amount of cancerous cells that are ablated in a porous medium is approximately the same as that in a continuous medium. The volume of cell ablation is about 6500 mm3 for two ideas. In addition, the degree of damage, computed from the Arrhenius integral method, and the ablated volume of the tumour endorse equality at the end of treatment. According to the results, similar to the continuous approach, the porous approach predicts the temperature and amount of volume of damaged cells. Conclusion: Therefore, it is possible to use the porous approach instead of the Pennes approach for tumour treatment.

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来源期刊
Journal of lasers in medical sciences
Journal of lasers in medical sciences RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
3.00
自引率
13.30%
发文量
24
期刊介绍: The "Journal of Lasers in Medical Sciences " is a scientific quarterly publication of the Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences. This journal received a scientific and research rank from the national medical publication committee. This Journal accepts original papers, review articles, case reports, brief reports, case series, photo assays, letters to the editor, and commentaries in the field of laser, or light in any fields of medicine such as the following medical specialties: -Dermatology -General and Vascular Surgery -Oncology -Cardiology -Dentistry -Urology -Rehabilitation -Ophthalmology -Otorhinolaryngology -Gynecology & Obstetrics -Internal Medicine -Orthopedics -Neurosurgery -Radiology -Pain Medicine (Algology) -Basic Sciences (Stem cell, Cellular and Molecular application and physic)
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