血液系统恶性肿瘤化疗诱导的周围神经病变动物模型:综述。

Ibrain Pub Date : 2022-12-22 DOI:10.1002/ibra.12086
Xiaoli Lv, Yingwei Mao, Song Cao, Yonghuai Feng
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引用次数: 1

摘要

化疗是治疗血液系统恶性肿瘤的主要方法之一。然而,化疗诱导的周围神经病变(CIPN)是化疗中最常见的长期毒性反应之一,CIPN的发生影响患者的生活质量,严重时可导致化疗中断,从而降低化疗的疗效。我们目前总结了现有的CIPN动物模型,包括几种常见动物模型的特征,如硼替佐米诱导的周围神经病变、长春新碱诱导的周围神经病和奥沙利铂诱导的周围病变。研究发现,CIPN可能导致诱发周围神经病变的行为、组织病理学和神经生理学变化。然而,CIPN的机制尚未完全阐明,尤其是预防和治疗方案需要改进。因此,本文综述了CIPN动物模型的研究进展,以及CIPN的可能机制和治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Animal models of chemotherapy-induced peripheral neuropathy for hematological malignancies: A review

Animal models of chemotherapy-induced peripheral neuropathy for hematological malignancies: A review

Chemotherapy is one of the main treatments for hematologic malignancies. However, chemotherapy-induced peripheral neuropathy (CIPN) is one of the most common long-term toxic reactions in chemotherapy, and the occurrence of CIPN affects patients’ quality of life and can cause interruption of chemotherapy in severe cases, thus reducing the efficacy of chemotherapy. We currently summarize the existing CIPN animal models, including the characteristics of several common animal models such as bortezomib-induced peripheral neuropathy, vincristine-induced peripheral neuropathy, and oxaliplatin-induced peripheral neuropathy. It was found that CIPN may lead to behavioral, histopathological, and neurophysiological changes inducing peripheral neuropathy. However, the mechanism of CIPN has not been fully elucidated, especially the prevention and treatment protocols need to be improved. Therefore, this review article summarizes the progress of research on CIPN animal models and the possible mechanisms and treatment of CIPN.

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