癌症患者心率变异性的评估。

Current health sciences journal Pub Date : 2023-04-01 Epub Date: 2023-06-30 DOI:10.12865/CHSJ.49.02.172
Mihai Petrescu, Ion Udriștoiu, Felicia Militaru, Alexandra-Roxana Petrescu, Georgică Târtea, Victor Raicea, Ana-Maria Ciurea, Ana-Maria Petrescu, Cristin Constantin Vere
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引用次数: 0

摘要

我们研究的目的是提供心率变异性(HRV)的评估,作为癌症(PCa)患者生存率的预测指标。我们进行了一项回顾性描述性研究。包括53例新诊断为胰腺癌症(PCa)的连续患者。最终,41名患者被纳入分析,其中14名患者至少存活到24个月的随访,27名患者在确诊后24个月内死亡。在开始任何治疗之前,对这些患者进行24小时动态心电图(ECG)监测,以确定心率变异性。为了确定HRV的临界值,分析了20名健康受试者的24小时动态心电图记录。除了心率分析外,还分析了HRV指标:SDNN、rMSSD、ULF和VLF。SDNN值低的患者的中位生存期为9个月,而SDNN值高的患者的平均生存期为15个月(危险比2.301,95%CI为0.9080-5.833,p=0.034)。尽管频域HRV指数值低与生存期降低有关,但没有记录到统计学上的显著差异。在新诊断为癌症的患者中,心率变异性指数的降低是一个负面的预后因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The Assessment of Heart Rate Variability in Patients with Pancreatic Cancer.

The Assessment of Heart Rate Variability in Patients with Pancreatic Cancer.

The Assessment of Heart Rate Variability in Patients with Pancreatic Cancer.

The Assessment of Heart Rate Variability in Patients with Pancreatic Cancer.
The aim of our study is to provide an assessment of heart rate variability (HRV) as a predictor for the survival of patients with pancreatic cancer (PCa). We conducted a retrospective, descriptive study. 53 consecutive patients who were newly diagnosed with pancreatic cancer (PCa), were included. In the end, 41 patients were included in the analysis, out of which 14 patients survived at least until the 24-month follow-up, while 27 patients died within 24 months from the diagnosis. These patients were monitored with 24-hour Holter electrocardiogram (ECG) prior to the initiation of any therapy for determining heart rate variability. To establish the cut-off values of HRV, 24-hour Holter ECG recordings of 20 healthy subjects were analyzed. In addition to heart rate analysis, HRV indices were also analyzed: SDNN, rMSSD, ULF and VLF. Median survival in patients with low value of SDNN was 9 months, compared to patients with hight SDNN where median survival was 15 months (Hazard ratio 2.301, 95% CI of ratio 0.9080 to 5.833, p= 0.034). Although low values of the HRV indices in the frequency domain were associated with reduced survival, no statistically significant differences were recorded. The reduction of heart rate variability indices is a negative prognostic factor in patients newly diagnosed with pancreatic cancer.
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