治疗铜绿假单胞菌感染的噬菌体。

3区 生物学 Q2 Biochemistry, Genetics and Molecular Biology
Salsabil Makky, Fatma Abdelrahman, Nouran Rezk, Maheswaran Easwaran, Ayman El-Shibiny
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引用次数: 0

摘要

铜绿假单胞菌被认为是对公众健康具有高度威胁的细菌之一。它获得了许多毒力因子和抗性基因,这使得传统抗生素难以控制。因此,噬菌体疗法(噬菌体疗法)是对抗多重耐药铜绿假单胞菌的抗生素的一种拟议替代方案。已经分离出许多噬菌体,它们对铜绿假单胞菌表现出广谱活性。本章报道了铜绿假单胞菌常见毒力因子及耐药基因的流行情况。此外,还强调了最近在噬菌体治疗领域针对铜绿假单胞菌的努力,包括野生型噬菌体、转基因噬菌体、噬菌体混合物,以及噬菌体与抗生素组合对抗浮游和生物膜形式的铜绿假单胞杆菌。本章还介绍了噬菌体治疗的最新规定。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Phages for treatment Pseudomonas aeruginosa infection.

Pseudomonas aeruginosa is denoted as one of the highly threatening bacteria to the public health. It has acquired many virulent factors and resistant genes that make it difficult to control with conventional antibiotics. Thus, bacteriophage therapy (phage therapy) is a proposed alternative to antibiotics to fight against multidrug-resistant P. aeruginosa. Many phages have been isolated that exhibit a broad spectrum of activity against P. aeruginosa. In this chapter, the common virulent factors and the prevalence of antibiotic-resistance genes in P. aeruginosa were reported. In addition, recent efforts in the field of phage therapy against P. aeruginosa were highlighted, including wild-type phages, genetically modified phages, phage cocktails, and phage in combination with antibiotics against P. aeruginosa in the planktonic and biofilm forms. Recent regulations on phage therapy were also covered in this chapter.

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来源期刊
CiteScore
5.00
自引率
0.00%
发文量
110
审稿时长
4-8 weeks
期刊介绍: Progress in Molecular Biology and Translational Science (PMBTS) provides in-depth reviews on topics of exceptional scientific importance. If today you read an Article or Letter in Nature or a Research Article or Report in Science reporting findings of exceptional importance, you likely will find comprehensive coverage of that research area in a future PMBTS volume.
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