库尔德人群中常见TLR4 SNPs的基因型频率:全球综述和非洲移民。

4区 生物学 Q2 Medicine
Sherko Subhan Niranji, Sirwan M A Al-Jaf
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引用次数: 1

摘要

Toll样受体(TLRs)是一种探索微生物分子的细胞先天免疫受体。例如,TLR4可以感应细菌脂多糖,诱导细胞因子和抗微生物肽对抗细菌。TLR4的单核苷酸多态性(SNPs)与感染性休克等疾病有关。因此,对常见SNPs的研究可能有助于解释疾病的发病机制和对感染的各种先天免疫反应。本研究使用限制性长度片段多态性(RFLP)研究了库尔德人群中两种常见TLR4 SNPs,Asp299Gly和Thr399Ile的基因型频率。在撒哈拉以南非洲、北非、西亚、欧亚大陆和东亚的不同人群中,TLR4 SNPs的全球频率也被用来推断人类迁徙和过去的定居点。RFLP数据表明,在库尔德人群中,两个SNP的基因型频率与伊朗或其他西亚人群相似,而伊朗或其他南亚人群又与欧亚人群相似,这表明过去由于迁徙、人口混合和共同祖先而混合。在全球范围内,纯合野生型TLR4变体的频率普遍存在,但纯合突变体在几乎所有全球种群中都很罕见或缺乏。杂合子的频率因种群而异。例如,在撒哈拉以南非洲,Asp299Gly SNP的频率高于Thr399Ile的频率,而在阿拉伯半岛,这两个SNP都以高频率存在。相比之下,东亚人群缺乏或具有非常低频率的两种感兴趣的TLR4 SNP。此外,TLR4 SNPs的共分离在一些人群中很常见,这可能表明与某些疾病有重要关联。未来的研究需要将TLR4 SNPs与疾病的耐药性或易感性联系起来。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Genotype Frequency of the Common TLR4 SNPs in a Kurdish Population: Global Reviews and Out-of-African Migrations.

Toll-like receptors (TLRs) are cellular innate immune receptors that explore microbial molecules. For instance, TLR4 can sense bacterial lipopolysaccharides, inducing cytokines and antimicrobial peptides against the bacteria. Single-nucleotide polymorphisms (SNPs) in TLR4 are associated with diseases such as septic shock. Therefore, investigations of common SNPs may help explain the pathogenesis of diseases and various innate immune responses to infections. This study investigated genotypic frequencies of the two common TLR4 SNPs, Asp299Gly and Thr399Ile, in a Kurdish population using restriction length fragment polymorphisms (RFLPs). Global frequencies of both TLR4 SNPs in different populations of sub-Saharan Africa, North Africa, western Asia, Eurasia, and East Asia were also used to infer human migrations and past settlements. The RFLP data demonstrate that, in the Kurdish population, the genotypic frequencies of both SNPs are similar to Iranian or other West Asian populations, which in turn are comparable to Eurasian populations, suggesting past admixture due to migrations, population intermixing, and common ancestry. Globally, the frequencies of the homozygous wild-types of TLR4 variants are prevalent, but homozygous mutants are rare or lacking in almost all global populations. Frequencies of the heterozygotes varied among populations. For instance, in sub-Saharan Africa the frequency of the Asp299Gly SNP is higher than that of Thr399Ile, whereas in the Arabian Peninsula both SNPs are present at high frequencies. In contrast, East Asian populations lack or have very low frequencies of both TLR4 SNPs of interest. Moreover, co-segregation of the TLR4 SNPs is common in some populations, which may indicate important associations with certain diseases. Future studies are required to link the TLR4 SNPs with either resistance or susceptibility to diseases.

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来源期刊
Human Biology
Human Biology 生物-生物学
CiteScore
1.90
自引率
0.00%
发文量
88
审稿时长
>12 weeks
期刊介绍: Human Biology publishes original scientific articles, brief communications, letters to the editor, and review articles on the general topic of biological anthropology. Our main focus is understanding human biological variation and human evolution through a broad range of approaches. We encourage investigators to submit any study on human biological diversity presented from an evolutionary or adaptive perspective. Priority will be given to interdisciplinary studies that seek to better explain the interaction between cultural processes and biological processes in our evolution. Methodological papers are also encouraged. Any computational approach intended to summarize cultural variation is encouraged. Studies that are essentially descriptive or concern only a limited geographic area are acceptable only when they have a wider relevance to understanding human biological variation. Manuscripts may cover any of the following disciplines, once the anthropological focus is apparent: human population genetics, evolutionary and genetic demography, quantitative genetics, evolutionary biology, ancient DNA studies, biological diversity interpreted in terms of adaptation (biometry, physical anthropology), and interdisciplinary research linking biological and cultural diversity (inferred from linguistic variability, ethnological diversity, archaeological evidence, etc.).
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