燃烧脂肪的甜味膨胀：高密度脂蛋白在能量稳态中的新作用。

IF 3.8 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Current opinion in lipidology Pub Date : 2023-12-01 Epub Date: 2023-10-05 DOI:10.1097/MOL.0000000000000904

Anatol Kontush, Maximiliano Martin, Fernando Brites

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引用次数: 0

摘要

综述目的：脂质和脂蛋白的代谢，包括高密度脂蛋白（HDL），在能量稳态中起着核心作用。然而，能量稳态和高密度脂蛋白之间关系的潜在机制仍然研究不足。最近的发现：现有证据表明高密度脂蛋白与能量稳态有关。循环高密度脂蛋白胆固醇（HDL-C）水平受能量产生的影响，随着静息代谢率的增加而升高。甘油三酯的脂解作为能量来源，可降低血浆残余胆固醇水平，增加HDL-C水平，并具有心脏保护作用。转向从碳水化合物中优先生产能量会产生相反的效果。综述：低HDL-C可能代表脂肪产生低效能量的生物标志物。当HDL-C评级反映燃烧脂肪产生的能量增加时，它可能是有益的。

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Sweet swell of burning fat: emerging role of high-density lipoprotein in energy homeostasis.

Purpose of review: Metabolism of lipids and lipoproteins, including high-density lipoprotein (HDL), plays a central role in energy homeostasis. Mechanisms underlying the relationship between energy homeostasis and HDL however remain poorly studied.

Recent findings: Available evidence reveals that HDL is implicated in energy homeostasis. Circulating high-density lipoprotein-cholesterol (HDL-C) levels are affected by energy production, raising with increasing resting metabolic rate. Lipolysis of triglycerides as a source of energy decreases plasma levels of remnant cholesterol, increases levels of HDL-C, and can be cardioprotective. Switch to preferential energy production from carbohydrates exerts opposite effects.

Summary: Low HDL-C may represent a biomarker of inefficient energy production from fats. HDL-C-raising can be beneficial when it reflects enhanced energy production from burning fat.

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来源期刊

Current opinion in lipidology 医学-内分泌学与代谢

CiteScore

6.70

自引率

4.50%

发文量

审稿时长

6-12 weeks

期刊介绍： With its easy-to-digest reviews on important advances in world literature, Current Opinion in Lipidology offers expert evaluation on a wide range of topics from six key disciplines including nutrition and metabolism, genetics and molecular biology, and hyperlipidaemia and cardiovascular disease. Published bimonthly, each issue covers in detail the most pertinent advances in these fields from the previous year. This is supplemented by a section of Bimonthly Updates, which deliver an insight into new developments at the cutting edge of the disciplines covered in the journal.