线粒体靶向衰老干预。

IF 7.8 2区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL
Sophia Z Liu, Ying Ann Chiao, Peter S Rabinovitch, David J Marcinek
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引用次数: 0

摘要

线粒体功能的变化在衰老和年龄相关疾病的基础生物学中起着关键作用。线粒体通常被认为是ATP产生和氧化剂产生的背景。然而,很明显,线粒体位于细胞信号传导的枢纽,在那里它们影响代谢产物、氧化还原和能量状态,这影响了许多有助于衰老生物学的因素,包括应激反应、蛋白稳定、表观遗传学和炎症。这引起了人们对确定线粒体靶向干预措施的兴趣,以延缓或逆转与年龄相关的功能下降,促进健康衰老。在这篇综述中,我们讨论了线粒体在细胞中的不同作用。然后,我们在临床前测试中重点介绍了一些最有前景的针对衰老线粒体的策略和化合物。最后,我们回顾了已进入临床试验的策略和化合物,以测试它们改善老年人健康的能力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Mitochondrial Targeted Interventions for Aging.

Changes in mitochondrial function play a critical role in the basic biology of aging and age-related disease. Mitochondria are typically thought of in the context of ATP production and oxidant production. However, it is clear that the mitochondria sit at a nexus of cell signaling where they affect metabolite, redox, and energy status, which influence many factors that contribute to the biology of aging, including stress responses, proteostasis, epigenetics, and inflammation. This has led to growing interest in identifying mitochondrial targeted interventions to delay or reverse age-related decline in function and promote healthy aging. In this review, we discuss the diverse roles of mitochondria in the cell. We then highlight some of the most promising strategies and compounds to target aging mitochondria in preclinical testing. Finally, we review the strategies and compounds that have advanced to clinical trials to test their ability to improve health in older adults.

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来源期刊
Cold Spring Harbor perspectives in medicine
Cold Spring Harbor perspectives in medicine MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
14.30
自引率
1.90%
发文量
44
审稿时长
4-8 weeks
期刊介绍: Cold Spring Harbor Perspectives in Medicine is a monthly online publication comprising reviews on different aspects of a variety of diseases, covering everything from the molecular and cellular bases of disease to translational medicine and new therapeutic strategies. Cold Spring Harbor Perspectives in Medicine is thus unmatched in its depth of coverage and represents an essential source where readers can find informed surveys and critical discussion of advances in molecular medicine.
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