多发性骨髓瘤的新生物疗法。

IF 15.1 1区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL
Annual review of medicine Pub Date : 2024-01-29 Epub Date: 2023-09-30 DOI:10.1146/annurev-med-050522-033815
Alfred L Garfall
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引用次数: 0

摘要

多发性骨髓瘤是骨髓浆细胞的癌症,约占血液系统恶性肿瘤的10%。尽管它通常是无法治愈的,但在过去25年中开发的一套引人注目的新疗法使大多数患者能够持久控制疾病。本文简要介绍了多发性骨髓瘤的临床特点以及现代疗法所利用的多发性肿瘤生物学方面。然后综述了目前和新兴的主要治疗模式,包括脑蛋白调节剂、蛋白酶体抑制剂、单克隆抗体、其他分子靶向疗法(selinexor、venetoclax)、嵌合抗原受体T细胞、T细胞结合双特异性抗体和抗体-药物偶联物。讨论了每种模式的作用机制和临床考虑因素。这些疗法在现代治疗途径中进行了组合和测序,在文章的结论中进行了讨论,近年来,这些疗法显著改善了多发性骨髓瘤患者的预后。《医学年度评论》第75卷预计最终在线出版日期为2024年1月。请参阅http://www.annualreviews.org/page/journal/pubdates用于修订估算。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
New Biological Therapies for Multiple Myeloma.

Multiple myeloma is a cancer of bone marrow plasma cells that represents approximately 10% of hematologic malignancies. Though it is typically incurable, a remarkable suite of new therapies developed over the last 25 years has enabled durable disease control in most patients. This article briefly introduces the clinical features of multiple myeloma and aspects of multiple myeloma biology that modern therapies exploit. Key current and emerging treatment modalities are then reviewed, including cereblon-modulating agents, proteasome inhibitors, monoclonal antibodies, other molecularly targeted therapies (selinexor, venetoclax), chimeric antigen receptor T cells, T cell-engaging bispecific antibodies, and antibody-drug conjugates. For each modality, mechanism of action and clinical considerations are discussed. These therapies are combined and sequenced in modern treatment pathways, discussed at the conclusion of the article, which have led to substantial improvements in outcomes for multiple myeloma patients in recent years.

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来源期刊
Annual review of medicine
Annual review of medicine 医学-医学:内科
CiteScore
24.90
自引率
0.00%
发文量
58
期刊介绍: The Annual Review of Medicine, which has been published since 1950, focuses on important advancements in diverse areas of medicine. These include AIDS/HIV, cardiology, clinical pharmacology, dermatology, endocrinology/metabolism, gastroenterology, genetics, immunology, infectious disease, neurology, oncology/hematology, pediatrics, psychiatry, pulmonology, reproductive medicine, and surgery. The journal's current volume has transitioned from a gated access model to an open access model through the Annual Reviews' Subscribe to Open program. All articles published in the journal are now available under a CC BY license.
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