评估肝转移对患者预后的影响：系统综述和荟萃分析。

IF 2.6 4区医学 Q3 ONCOLOGY

Cancer journal Pub Date : 2023-09-01 DOI:10.1097/PPO.0000000000000683

Jessica J Waninger, Vincent T Ma, Zoey Chopra, Ashley N Pearson, Michael D Green

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引用次数: 0

摘要

摘要：肝脏是许多原发性恶性肿瘤的常见转移部位，但对生存率的定量影响尚不清楚。我们对83项研究（604853名患者）进行了系统回顾和荟萃分析，根据原发肿瘤类型和治疗方案评估与肝转移相关的总体风险。所有纳入研究的总生存风险比（HR）为1.77（95%置信区间（CI），1.62-1.93）。癌症原发性患者表现最差（HR，2.37；95%置信区间，1.64-3.44），接受免疫疗法治疗的患者也是如此（HR，1.86；95%可信区间，1.42-2.42）。肝转移对生存产生负面影响，需要采取新的疾病管理方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Evaluation of the Prognostic Role of Liver Metastases on Patient Outcomes: Systematic Review and Meta-analysis.

Abstract: The liver is a common site of metastasis for many primary malignancies, but the quantitative impact on survival is unknown. We performed a systematic review and meta-analysis of 83 studies (604,853 patients) assessing the overall hazard associated with liver metastases by primary tumor type and treatment regimen. The pooled overall survival hazard ratio (HR) for all included studies was 1.77 (95% confidence interval [CI], 1.62-1.93). Patients with breast cancer primaries fared the worst (HR, 2.37; 95% CI, 1.64-3.44), as did patients treated with immunotherapies (HR, 1.86; 95% CI, 1.42-2.42). Liver metastases negatively impact survival, necessitating new approaches to disease management.

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来源期刊

Cancer journal 医学-肿瘤学

CiteScore

3.90

自引率

0.00%

发文量

102

审稿时长

7.5 months

期刊介绍： The Cancer Journal: The Journal of Principles & Practice of Oncology provides an integrated view of modern oncology across all disciplines. The Journal publishes original research and reviews, and keeps readers current on content published in the book Cancer: Principles & Practice of Oncology.