消融部分激光治疗对人类皮肤的长期和短期影响:网络分析。

IF 1.4 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Journal of lasers in medical sciences Pub Date : 2023-08-27 eCollection Date: 2023-01-01 DOI:10.34172/jlms.2023.27
Zahra Razzaghi, Babak Arjmand, Mostafa Rezaei Tavirani, Maryam Hamzeloo-Moghadam, Mohammad Rostami Nejad, Reza Mohamoud Robati
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引用次数: 0

摘要

引言:研究人员已经对激光辐射的时间依赖性效应进行了研究。了解激光时程效应的分子机制需要对相关基因进行分子评估和功能评估。在本研究中,通过蛋白质-蛋白质相互作用(PPI)网络分析和基因本体论富集,评估了4周后重复治疗以及激光照射7天后与人类皮肤上一天相比基因表达改变的重要性。方法:从基因表达综合征(GEO)中提取差异表达基因(DEGs),并通过PPI网络分析进行评估。通过基因本体论丰富了关键的DEG。相关的生物过程和生物化学途径分别从“GO生物过程”和“京都基因和基因组百科全书”(KEGG)中检索到。结果:第一次治疗4周后重复激光治疗对治疗效果没有显著影响。63个显著的DEG和6类生物术语区分了治疗后7天的样本和治疗后1天的个体。研究的DEG被组织成两个具有一定功能的簇。结论:根据激光治疗后的发现,完成DNA生物合成和皮肤角质化等关键过程需要几天时间。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Long and Short-terms Effects of Ablative Fractional Laser Therapy on Human Skin: A Network Analysis.

Introduction: Time-dependent effects of laser radiation have been investigated by researchers. An understanding of the molecular mechanism of the time course effect of the laser needs molecular assessment and function evaluation of the related genes. In the present study, the importance of repetition of treatment after 4 weeks and gene expression alteration after 7 days of laser radiation versus one day on the human skin was evaluated via protein-protein interaction (PPI) network analysis and gene ontology enrichment. Methods: The differentially expressed genes (DEGs) were extracted from Gene Expression Omnibus (GEO) and assessed via PPI network analysis. The critical DEGs were enriched via gene ontology. The related biological processes and biochemical pathways were retrieved from "GO-Biological process" and "Kyoto Encyclopedia of Genes and Genomes" (KEGG) respectively. Results: The repetition of laser therapy after 4 weeks of the first treatment did not have a significant effect on treatment efficacy. Sixty-three significant DEGs and six classes of biological terms discriminated the samples seven days after the treatment from individuals one day after the treatment. The studied DEGs were organized into two clusters with certain functions. Conclusion: Based on the findings after laser therapy, several days are required to complete the critical processes such as DNA biosynthesis and skin cornification.

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来源期刊
Journal of lasers in medical sciences
Journal of lasers in medical sciences RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
3.00
自引率
13.30%
发文量
24
期刊介绍: The "Journal of Lasers in Medical Sciences " is a scientific quarterly publication of the Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences. This journal received a scientific and research rank from the national medical publication committee. This Journal accepts original papers, review articles, case reports, brief reports, case series, photo assays, letters to the editor, and commentaries in the field of laser, or light in any fields of medicine such as the following medical specialties: -Dermatology -General and Vascular Surgery -Oncology -Cardiology -Dentistry -Urology -Rehabilitation -Ophthalmology -Otorhinolaryngology -Gynecology & Obstetrics -Internal Medicine -Orthopedics -Neurosurgery -Radiology -Pain Medicine (Algology) -Basic Sciences (Stem cell, Cellular and Molecular application and physic)
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