鹅掌楸的安全性评价。叶提取物:急性和亚慢性研究。

Q3 Agricultural and Biological Sciences
Zulham, Anas Subarnas, Gofarana Wilar, Yasmiwar Susilawati, Anis Yohana Chaerunisaa
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引用次数: 0

摘要

<;b>;背景和目的:</b><;i>;橄榄Schleichera oleosa</i>;(Sapindaceae)已被报道在传统医学中有用,并且具有一些潜在的药理活性,如抗癌、抗氧化和抗菌活性。本研究旨在评估其安全性,以提供<;i>;S.oleosa</i>;作为草药<;b>;材料和方法:</b>;提取物的安全性评估是通过分别在小鼠(雄性和雌性)和大鼠(雄性和雄性)中测试急性和亚慢性毒性来进行的。在急性毒性试验中使用的剂量为1000、2000、3000、4000和5000 mg kg<;sup>;1</sup>;体重和亚慢性治疗中的体重分别为100、200和400mg/kg<;sup>;1</sup>;体重<;b>;结果:</b>;在急性毒性试验中,<;i>;S.oleosa</i>;所有剂量的叶提取物表明LD<;sub>;50</sub>;提取物的值高于5000mg kg<;sup>;1</sup>;b.wt.,这表明根据毒性标准,该提取物实际上是无毒的。此外,亚慢性毒性试验发现,对雄性和雌性大鼠以每天100和200mg的剂量施用提取物<;sup>;1</sup>;b.wt.,90天内没有引起血液学、血液生化和肝、肾、心脏、淋巴和肺的组织病理学图像的任何显著变化。尽管白细胞计数显著增加,但长期使用<;i>;S.oleosa</i>;叶提取物相对安全<;b>;结论:</b>;该结果提供了关于<;i>;S.oleosa</i>;用作草药的叶子。然而,还需要进行进一步的研究来验证这种活性及其长期使用的安全性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Safety Assessment of Schleichera oleosa Lour. Leaves Extract: Acute and Subchronic Studies.

<b>Background and Objective:</b> <i>Schleichera oleosa</i> (Sapindaceae) has been reported to be useful in traditional medicine and it has some potential pharmacological activities, such as anticancer, antioxidant and antimicrobial activities. This study aimed to assess its safety to provide complete data required for the development of <i>S. oleosa</i> as herbal medicine. <b>Materials and Methods:</b> The safety assessment of the extract was carried out by testing acute and subchronic toxicity in mice (male and female) and rats (male and female), respectively. The doses used in the acute toxicity test were 1000, 2000, 3000, 4000 and 5000 mg kg<sup>1</sup> of body weight and those in the subchronic treatment were 100, 200 and 400 mg kg<sup>1</sup> of body weight. <b>Results:</b> In the acute toxicity test, the <i>S. oleosa</i> leaf extract at all doses indicated that the LD<sub>50</sub> value of the extract was higher than 5000 mg kg<sup>1</sup> b.wt., which suggested that this extract is practically non-toxic according to the toxicity criteria. Furthermore, the subchronic toxicity test found that the administration of the extract to male and female rats at a daily dose of 100 and 200 mg kg<sup>1</sup> b.wt., for 90 days did not cause any significant change in blood haematology, blood biochemistry and histopathological picture of liver, kidney, heart, lymph and lung. Despite there being a significant increase in white blood counts, long-term use of the <i>S. oleosa</i> leaf extract is relatively safe. <b>Conclusion:</b> The results provided evidence regarding the potential of <i>S. oleosa</i> leaves to be used as herbal medicine. However, further research needs to be done to verify that activity and its safety in long-term use.

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来源期刊
Pakistan Journal of Biological Sciences
Pakistan Journal of Biological Sciences Agricultural and Biological Sciences-Agronomy and Crop Science
CiteScore
1.90
自引率
0.00%
发文量
102
期刊介绍: Pakistan Journal of Biological Sciences (PJBS) is an international, peer-reviewed and well indexed scientific journal seeks to promote and disseminate the knowledge of biological sciences by publishing outstanding research in the field. Scope of the journal includes: Cell biology, developmental biology, structural biology, microbiology, entomology, toxicology, molecular biology & genetics, biochemistry, biotechnology, biodiversity, ecology, marine biology, plant biology and bioinformatics.
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