胰腺内分泌肿瘤分泌激素的免疫组织化学评价。

IF 1.6 4区生物学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Biotechnic & Histochemistry Pub Date : 2023-11-01 Epub Date: 2023-10-31 DOI:10.1080/10520295.2023.2260307

Anne Mones, Sheila Criswell

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引用次数: 0

摘要

胰腺的内分泌成分主要位于朗格汉斯岛，但在腺泡细胞和导管上皮中也以单细胞的形式存在。目前认为胰腺内分泌肿瘤（PET）是由位于导管上皮内的多能干细胞引起的，而不是由现有的内分泌细胞引起的。胰岛细胞成分包括α、β、PP、δ和ε细胞，它们分别分泌胰高血糖素、胰岛素、胰腺多肽、生长抑素和胃促生长素。我们研究了24个福尔马林固定石蜡包埋的PET的免疫组织化学标记，以确定哪些激素产生最频繁。胰高血糖素是PETS中最常分泌的激素（83%），其次是胰岛素、胃促生长素、胰多肽和生长抑素。

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Immunohistochemical evaluation of hormones secreted by pancreatic endocrine tumors.

The endocrine component of the pancreas is located primarily in the islets of Langerhans, but is also found as single cells among the acinar cells and duct epithelium. It currently is thought that endocrine tumors of the pancreas (PETs) arise from pluripotent stem cells located within the ductal epithelium rather than from existing endocrine cells. Islet cell components include alpha, beta, PP, delta and epsilon cells, which secrete glucagon, insulin, pancreatic polypeptide, somatostatin and ghrelin, respectively. We investigated immunohistochemical labeling of 24 formalin fixed paraffin embedded PETs to identify which hormones were produced most frequently. Glucagon was the most frequently secreted hormone (83%) in PETS followed by insulin, ghrelin, pancreatic polypeptide and somatostatin.

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来源期刊

Biotechnic & Histochemistry 生物-生物工程与应用微生物

CiteScore

3.40

自引率

6.20%

发文量

审稿时长

6-12 weeks

期刊介绍： Biotechnic & Histochemistry (formerly Stain technology) is the official publication of the Biological Stain Commission. The journal has been in continuous publication since 1926. Biotechnic & Histochemistry is an interdisciplinary journal that embraces all aspects of techniques for visualizing biological processes and entities in cells, tissues and organisms; papers that describe experimental work that employs such investigative methods are appropriate for publication as well. Papers concerning topics as diverse as applications of histochemistry, immunohistochemistry, in situ hybridization, cytochemical probes, autoradiography, light and electron microscopy, tissue culture, in vivo and in vitro studies, image analysis, cytogenetics, automation or computerization of investigative procedures and other investigative approaches are appropriate for publication regardless of their length. Letters to the Editor and review articles concerning topics of special and current interest also are welcome.