钒催化2-氰基吡嗪水合制备吡嗪酰胺，具有独特的底物特异性。

IF 3.5 3区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemistry - An Asian Journal Pub Date : 2023-09-27 DOI:10.1002/asia.202300741

Zhongxu Guo, Dr. Zhongtian Du, Yanbin Zhao, Xiaoyu Shen, Prof. Dr. Changhai Liang

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引用次数: 0

摘要

吡嗪酰胺是治疗肺结核的重要药物。2-氰基吡嗪催化水合制备吡嗪酰胺具有较高的原子经济性，具有重大的经济意义。非均相非贵过渡金属催化腈在中性反应条件下的水合反应将相当有吸引力。本文制备了钒-氮-碳材料，并将其用于以水为溶剂和反应物的腈的选择性水合。2-氰基吡嗪能顺利转化为吡嗪酰胺，具有独特的底物特异性。具有不同N和O原子的添加剂由于在反应体系中的竞争吸附/配位，可以显著影响2-氰基吡嗪的水合作用。这项工作为非贵金属催化腈的水合反应提供了一种新的途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Vanadium-catalyzed Hydration of 2-Cyanopyrazine to Pyrazinamide with Unique Substrate Specificity

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Vanadium-catalyzed Hydration of 2-Cyanopyrazine to Pyrazinamide with Unique Substrate Specificity

Pyrazinamide is an important medicine used for the treatment of tuberculosis(TB). The preparation of pyrazinamide via catalytic hydration of 2-cyanopyrazine is of great economic interest with high atomic economy. Heterogeneous non-precious transition metal-catalyzed hydration of nitriles under neutral reaction conditions would be rather attractive. Herein vanadium-nitrogen-carbon materials were fabricated and employed for selective hydration of nitriles using water as both the solvent and reactant. 2-Cyanopyrazine could be smoothly converted into to pyrazinamide with unique substrate specificity. Additives with different N and O atoms could significantly affect hydration of 2-cyanopyrazine due to competitive adsorption/coordination in the reaction system. This work provides a new approach for non-precious metal catalyzed hydration of nitriles.

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来源期刊

Chemistry - An Asian Journal 化学-化学综合

CiteScore

7.00

自引率

2.40%

发文量

535

审稿时长

1.3 months

期刊介绍： Chemistry—An Asian Journal is an international high-impact journal for chemistry in its broadest sense. The journal covers all aspects of chemistry from biochemistry through organic and inorganic chemistry to physical chemistry, including interdisciplinary topics. Chemistry—An Asian Journal publishes Full Papers, Communications, and Focus Reviews. A professional editorial team headed by Dr. Theresa Kueckmann and an Editorial Board (headed by Professor Susumu Kitagawa) ensure the highest quality of the peer-review process, the contents and the production of the journal. Chemistry—An Asian Journal is published on behalf of the Asian Chemical Editorial Society (ACES), an association of numerous Asian chemical societies, and supported by the Gesellschaft Deutscher Chemiker (GDCh, German Chemical Society), ChemPubSoc Europe, and the Federation of Asian Chemical Societies (FACS).