{"title":"使用不同指标在两种PET系统之间进行肿瘤评估的研究：PET/CT和PET/MRI系统之间的比较。","authors":"Hirotoshi Hotsumi, Shirou Ishii, Hiroki Suenaga, Shigeyasu Sugawara, Kenji Fukushima, Hiroshi Ito","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>This study aimed to determine the comparability of tumor-uptake indices of <sup>18</sup>F-FDG in positron emission tomography/computed tomography (PET/CT) and positron emission tomography/magnetic resonance imaging (PET/MRI). 2-[fluorine-18]-fluoro-2-deoxy-D-glucose (FDG) PET/CT and PET/MRI were performed on 55 patients with confirmed primary malignancies. PET/CT preceded PET/MRI in all examinations. Accumulation of <sup>18</sup>F-FDG in lesions and normal organs (brain, liver) was measured. Maximum and peak standardized uptake values (SUVs; SUV<sub>max</sub> and SUV<sub>peak</sub>, respectively), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) with margin thresholds of SUV of 50% (MTV<sub>50%</sub>; TLG<sub>50%</sub>, respectively) were measured as indices for comparison of measurements in tumors. Comparative indices with tumor SUV<sub>max</sub> and liver ratio (TLR<sub>max</sub>), brain ratio (TBR<sub>max</sub>) were calculated. These indices were compared between PET/CT and PET/MRI examinations. The data measured using PET/CT and PET/MRI showed significant correlations for all tumor indices. The correlation was strongest for SUV<sub>peak</sub> (r = 0.933), followed by TBR<sub>max</sub> (r = 0.929); and the index ratio of (PET/CT)/(PET/MRI) data was close to 1.0 for TLR<sub>max</sub> (1.00 ± 0.22) and TBR<sub>max</sub> (1.01 ± 0.21), followed by MTV<sub>50%</sub> (0.82 ± 0.33) and TLG<sub>50%</sub> (1.18 ± 0.45). The values of all indices showed strong correlations between PET/CT and PET/MRI examinations. Among them, TLR<sub>max</sub>, TBR<sub>max</sub>, MTV<sub>50%</sub>, and TLG<sub>50%</sub> showed a close value and may be useful for comparison of tumor evaluation between two PET systems.</p>","PeriodicalId":7572,"journal":{"name":"American journal of nuclear medicine and molecular imaging","volume":null,"pages":null},"PeriodicalIF":2.0000,"publicationDate":"2023-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10509291/pdf/ajnmmi0013-0156.pdf","citationCount":"0","resultStr":"{\"title\":\"Investigation of tumor assessment between two PET systems using various indices: comparison between PET/CT and PET/MRI systems.\",\"authors\":\"Hirotoshi Hotsumi, Shirou Ishii, Hiroki Suenaga, Shigeyasu Sugawara, Kenji Fukushima, Hiroshi Ito\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>This study aimed to determine the comparability of tumor-uptake indices of <sup>18</sup>F-FDG in positron emission tomography/computed tomography (PET/CT) and positron emission tomography/magnetic resonance imaging (PET/MRI). 2-[fluorine-18]-fluoro-2-deoxy-D-glucose (FDG) PET/CT and PET/MRI were performed on 55 patients with confirmed primary malignancies. PET/CT preceded PET/MRI in all examinations. Accumulation of <sup>18</sup>F-FDG in lesions and normal organs (brain, liver) was measured. Maximum and peak standardized uptake values (SUVs; SUV<sub>max</sub> and SUV<sub>peak</sub>, respectively), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) with margin thresholds of SUV of 50% (MTV<sub>50%</sub>; TLG<sub>50%</sub>, respectively) were measured as indices for comparison of measurements in tumors. Comparative indices with tumor SUV<sub>max</sub> and liver ratio (TLR<sub>max</sub>), brain ratio (TBR<sub>max</sub>) were calculated. These indices were compared between PET/CT and PET/MRI examinations. The data measured using PET/CT and PET/MRI showed significant correlations for all tumor indices. The correlation was strongest for SUV<sub>peak</sub> (r = 0.933), followed by TBR<sub>max</sub> (r = 0.929); and the index ratio of (PET/CT)/(PET/MRI) data was close to 1.0 for TLR<sub>max</sub> (1.00 ± 0.22) and TBR<sub>max</sub> (1.01 ± 0.21), followed by MTV<sub>50%</sub> (0.82 ± 0.33) and TLG<sub>50%</sub> (1.18 ± 0.45). The values of all indices showed strong correlations between PET/CT and PET/MRI examinations. Among them, TLR<sub>max</sub>, TBR<sub>max</sub>, MTV<sub>50%</sub>, and TLG<sub>50%</sub> showed a close value and may be useful for comparison of tumor evaluation between two PET systems.</p>\",\"PeriodicalId\":7572,\"journal\":{\"name\":\"American journal of nuclear medicine and molecular imaging\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2023-08-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10509291/pdf/ajnmmi0013-0156.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"American journal of nuclear medicine and molecular imaging\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"American journal of nuclear medicine and molecular imaging","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
Investigation of tumor assessment between two PET systems using various indices: comparison between PET/CT and PET/MRI systems.
This study aimed to determine the comparability of tumor-uptake indices of 18F-FDG in positron emission tomography/computed tomography (PET/CT) and positron emission tomography/magnetic resonance imaging (PET/MRI). 2-[fluorine-18]-fluoro-2-deoxy-D-glucose (FDG) PET/CT and PET/MRI were performed on 55 patients with confirmed primary malignancies. PET/CT preceded PET/MRI in all examinations. Accumulation of 18F-FDG in lesions and normal organs (brain, liver) was measured. Maximum and peak standardized uptake values (SUVs; SUVmax and SUVpeak, respectively), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) with margin thresholds of SUV of 50% (MTV50%; TLG50%, respectively) were measured as indices for comparison of measurements in tumors. Comparative indices with tumor SUVmax and liver ratio (TLRmax), brain ratio (TBRmax) were calculated. These indices were compared between PET/CT and PET/MRI examinations. The data measured using PET/CT and PET/MRI showed significant correlations for all tumor indices. The correlation was strongest for SUVpeak (r = 0.933), followed by TBRmax (r = 0.929); and the index ratio of (PET/CT)/(PET/MRI) data was close to 1.0 for TLRmax (1.00 ± 0.22) and TBRmax (1.01 ± 0.21), followed by MTV50% (0.82 ± 0.33) and TLG50% (1.18 ± 0.45). The values of all indices showed strong correlations between PET/CT and PET/MRI examinations. Among them, TLRmax, TBRmax, MTV50%, and TLG50% showed a close value and may be useful for comparison of tumor evaluation between two PET systems.
期刊介绍：
The scope of AJNMMI encompasses all areas of molecular imaging, including but not limited to: positron emission tomography (PET), single-photon emission computed tomography (SPECT), molecular magnetic resonance imaging, magnetic resonance spectroscopy, optical bioluminescence, optical fluorescence, targeted ultrasound, photoacoustic imaging, etc. AJNMMI welcomes original and review articles on both clinical investigation and preclinical research. Occasionally, special topic issues, short communications, editorials, and invited perspectives will also be published. Manuscripts, including figures and tables, must be original and not under consideration by another journal.
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