卡格列净通过血红素加氧酶-1介导的途径改善异丙肾上腺素诱导的心肌细胞氧化应激的作用。

IF 1.6 4区生物学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Biotechnic & Histochemistry Pub Date : 2023-11-01 Epub Date: 2023-10-31 DOI:10.1080/10520295.2023.2262390

Ahmed Ahmed, Dina Abdel-Rahman, Ehab M Hantash

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引用次数: 0

摘要

卡格列净（CZ）通常用于治疗2型糖尿病（T2DM）；它还可以降低心肌梗死的风险。我们使用80只白化Wistar大鼠来研究CZ对异丙肾上腺素（ISO）引起的氧化应激的心脏保护潜力。我们发现ISO刺激活性氧的产生，并且由于核因子红细胞2型相关因子2以及血红素加氧酶1介导的级联反应的增强，给予CZ导致抗氧化剂的上调和氧化剂的下调。CZ单药治疗可能对糖尿病患者起到心脏保护作用。CZ具有强大的抗氧化潜力，可改善ISO给药引起的心脏损伤。

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Role of canagliflozin in ameliorating isoprenaline induced cardiomyocyte oxidative stress via the heme oxygenase-1 mediated pathway.

Canagliflozin (CZ) is commonly prescribed for management of type-2 diabetes mellitus (T2DM); it also can reduce the risk of myocardial infarction. We used 80 albino Wistar rats to investigate the cardioprotective potential of CZ against oxidative stress caused by administration of isoprenaline (ISO). We found that ISO stimulates production of reactive oxygen species and that CZ administration caused up-regulation of antioxidants and down-regulation of oxidants due to nuclear factor erythroid-2 related factor-2, as well as by enhancement of the heme oxygenase-1 mediated cascade. CZ monotherapy may play a cardioprotective role in diabetic patients. CZ possesses strong antioxidant potential that ameliorates cardiac damage induced by ISO administration.

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来源期刊

Biotechnic & Histochemistry 生物-生物工程与应用微生物

CiteScore

3.40

自引率

6.20%

发文量

审稿时长

6-12 weeks

期刊介绍： Biotechnic & Histochemistry (formerly Stain technology) is the official publication of the Biological Stain Commission. The journal has been in continuous publication since 1926. Biotechnic & Histochemistry is an interdisciplinary journal that embraces all aspects of techniques for visualizing biological processes and entities in cells, tissues and organisms; papers that describe experimental work that employs such investigative methods are appropriate for publication as well. Papers concerning topics as diverse as applications of histochemistry, immunohistochemistry, in situ hybridization, cytochemical probes, autoradiography, light and electron microscopy, tissue culture, in vivo and in vitro studies, image analysis, cytogenetics, automation or computerization of investigative procedures and other investigative approaches are appropriate for publication regardless of their length. Letters to the Editor and review articles concerning topics of special and current interest also are welcome.