与海洋生物一起拥抱抗菌肽时代。

IF 12.7 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Pengyu Chen , Ting Ye , Chunyuan Li , Praveen Praveen , Zhangli Hu , Wenyi Li , Chenjing Shang
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引用次数: 0

摘要

涵盖范围:2018年至2021年6月传统抗生素的效率因抗生素耐药性病原微生物的增殖而受到损害,因此需要寻求创新的治疗剂。抗菌肽(AMP)是自然界中普遍存在的宿主防御肽的一部分,对细菌、真菌和病毒表现出广泛的活性,提供了一种极具前景的候选解决方案。AMP的功效经常可以通过改变其氨基酸序列或结构调整来增强。鉴于海洋生物形式的巨大储量及其独特的生态系统,海洋AMPs是寻找从天然来源提取的替代肽模板的新兴焦点。鉴定和表征技术的进步加速了海洋AMP的发现,从而刺激了AMP的定制、优化和合成研究工作。这篇综述概述了最近与海洋AMPs有趣特性有关的发现。重点将放在海洋AMP的翻译后修饰(PTM)上,以及它们如何影响功能和效力。此外,这篇综述考虑了海洋PTM可能支持更大规模、异源AMP制造计划的方式,为这些重要生物分子的转化应用提供了见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Embracing the era of antimicrobial peptides with marine organisms

Embracing the era of antimicrobial peptides with marine organisms

Embracing the era of antimicrobial peptides with marine organisms

Covering: 2018 to Jun of 2023

The efficiency of traditional antibiotics has been undermined by the proliferation of antibiotic-resistant pathogenic microorganisms, necessitating the pursuit of innovative therapeutic agents. Antimicrobial peptides (AMPs), which are part of host defence peptides found ubiquitously in nature, exhibiting a wide range of activity towards bacteria, fungi, and viruses, offer a highly promising candidate solution. The efficacy of AMPs can frequently be augmented via alterations to their amino acid sequences or structural adjustments. Given the vast reservoir of marine life forms and their distinctive ecosystems, marine AMPs stand as a burgeoning focal point in the quest for alternative peptide templates extracted from natural sources. Advances in identification and characterization techniques have accelerated the discoveries of marine AMPs, thereby stimulating AMP customization, optimization, and synthesis research endeavours. This review presents an overview of recent discoveries related to the intriguing qualities of marine AMPs. Emphasis will be placed upon post-translational modifications (PTMs) of marine AMPs and how they may impact functionality and potency. Additionally, this review considers ways in which marine PTM might support larger-scale, heterologous AMP manufacturing initiatives, providing insights into translational applications of these important biomolecules.

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来源期刊
ACS Central Science
ACS Central Science Chemical Engineering-General Chemical Engineering
CiteScore
25.50
自引率
0.50%
发文量
194
审稿时长
10 weeks
期刊介绍: ACS Central Science publishes significant primary reports on research in chemistry and allied fields where chemical approaches are pivotal. As the first fully open-access journal by the American Chemical Society, it covers compelling and important contributions to the broad chemistry and scientific community. "Central science," a term popularized nearly 40 years ago, emphasizes chemistry's central role in connecting physical and life sciences, and fundamental sciences with applied disciplines like medicine and engineering. The journal focuses on exceptional quality articles, addressing advances in fundamental chemistry and interdisciplinary research.
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