{"title":"评估CpG寡脱氧核苷酸刺激的免疫反应。","authors":"Mieko Hayashi, Makoto Kuwahara, Miwa Ogata, Naoko Miyao-Kurosaki, Takayuki Abel, Ryouji Ueki, Mayuka Yano, Masayuki Fujii, Gunther Hartmann, Hiroshi Takaku","doi":"10.1093/nass/3.1.323","DOIUrl":null,"url":null,"abstract":"<p><p>CpG oligonucleotides have recently been highlighted as an immunomodulator that biases toward a Th1-dominant phenotype. To substantiate the synergism between CpG-ODNs and Ag, we introduced a linked conjugate between CpG-ODNs and Ag and the antiviral effect of antigen-conjugated CpG-ODNs therapy following an infection of mice with the influenza virus A. We found that the conjugate inhibited the influenza virus infection more efficiently than the coadministration of the unconjugated CpG-ODNs and the Ag mixture. CpG-ODNs is effective in immunity induction and will be useful in treating virus infections.</p>","PeriodicalId":86149,"journal":{"name":"Nucleic acids research. Supplement (2001)","volume":" 3","pages":"323-4"},"PeriodicalIF":0.0000,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1093/nass/3.1.323","citationCount":"7","resultStr":"{\"title\":\"Evaluating the immune responses stimulated by CpG oligodeoxynucleotides.\",\"authors\":\"Mieko Hayashi, Makoto Kuwahara, Miwa Ogata, Naoko Miyao-Kurosaki, Takayuki Abel, Ryouji Ueki, Mayuka Yano, Masayuki Fujii, Gunther Hartmann, Hiroshi Takaku\",\"doi\":\"10.1093/nass/3.1.323\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>CpG oligonucleotides have recently been highlighted as an immunomodulator that biases toward a Th1-dominant phenotype. To substantiate the synergism between CpG-ODNs and Ag, we introduced a linked conjugate between CpG-ODNs and Ag and the antiviral effect of antigen-conjugated CpG-ODNs therapy following an infection of mice with the influenza virus A. We found that the conjugate inhibited the influenza virus infection more efficiently than the coadministration of the unconjugated CpG-ODNs and the Ag mixture. CpG-ODNs is effective in immunity induction and will be useful in treating virus infections.</p>\",\"PeriodicalId\":86149,\"journal\":{\"name\":\"Nucleic acids research. Supplement (2001)\",\"volume\":\" 3\",\"pages\":\"323-4\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2003-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1093/nass/3.1.323\",\"citationCount\":\"7\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nucleic acids research. Supplement (2001)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1093/nass/3.1.323\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nucleic acids research. Supplement (2001)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1093/nass/3.1.323","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Evaluating the immune responses stimulated by CpG oligodeoxynucleotides.
CpG oligonucleotides have recently been highlighted as an immunomodulator that biases toward a Th1-dominant phenotype. To substantiate the synergism between CpG-ODNs and Ag, we introduced a linked conjugate between CpG-ODNs and Ag and the antiviral effect of antigen-conjugated CpG-ODNs therapy following an infection of mice with the influenza virus A. We found that the conjugate inhibited the influenza virus infection more efficiently than the coadministration of the unconjugated CpG-ODNs and the Ag mixture. CpG-ODNs is effective in immunity induction and will be useful in treating virus infections.
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