{"title":"褐藻二醇A-C:来自未描述褐藻科sp. SGSF723的三个新化合物。","authors":"Lu Si, Yao Liu, Tingting Du, Wei Meng, Lijian Xu","doi":"10.3390/jof8111190","DOIUrl":null,"url":null,"abstract":"<p><p>Fungi in forest litter are diverse as decomposers but natural products from these fungi are rarely investigated, especially for their antimicrobial activities against crop diseases. In this study, fungal isolate SGSF723 with antimicrobial activities was cultured. A multi-gene phylogenetic analysis showed SGSF723 was an undescribed species in the family Phaeosphaeriaceae. By bio-guided assay, three new compounds (Phaeosphaeridiols A-C) and two known compounds were purified from the ethyl acetate extract. The structures of Phaeosphaeridiols A-C were elucidated as 2-(2'-butenyl)-5 (3″-pentene)-1,3-benzenediol (<b>1</b>), 2-(2'-butenyl)-5-(3″S,4″S-pentane diol)-1,3-benzenediol (<b>2</b>), and 3-(4'-(2″-butenyl)-3',5'-benzenediol phenol)-2-acrylic acid (<b>3</b>) by 2D NMR, HRESIMS, and Mosher's method. Phaeosphaeridiols A-C exhibited moderate or weak antimicrobial activities against plant pathogens by 96-well plate and spore germination assays.</p>","PeriodicalId":520671,"journal":{"name":"Journal of fungi (Basel, Switzerland)","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9697633/pdf/","citationCount":"0","resultStr":"{\"title\":\"Phaeosphaeridiols A-C: Three New Compounds from Undescribed <i>Phaeosphaeriaceae</i> sp. SGSF723.\",\"authors\":\"Lu Si, Yao Liu, Tingting Du, Wei Meng, Lijian Xu\",\"doi\":\"10.3390/jof8111190\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Fungi in forest litter are diverse as decomposers but natural products from these fungi are rarely investigated, especially for their antimicrobial activities against crop diseases. In this study, fungal isolate SGSF723 with antimicrobial activities was cultured. A multi-gene phylogenetic analysis showed SGSF723 was an undescribed species in the family Phaeosphaeriaceae. By bio-guided assay, three new compounds (Phaeosphaeridiols A-C) and two known compounds were purified from the ethyl acetate extract. The structures of Phaeosphaeridiols A-C were elucidated as 2-(2'-butenyl)-5 (3″-pentene)-1,3-benzenediol (<b>1</b>), 2-(2'-butenyl)-5-(3″S,4″S-pentane diol)-1,3-benzenediol (<b>2</b>), and 3-(4'-(2″-butenyl)-3',5'-benzenediol phenol)-2-acrylic acid (<b>3</b>) by 2D NMR, HRESIMS, and Mosher's method. Phaeosphaeridiols A-C exhibited moderate or weak antimicrobial activities against plant pathogens by 96-well plate and spore germination assays.</p>\",\"PeriodicalId\":520671,\"journal\":{\"name\":\"Journal of fungi (Basel, Switzerland)\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-11-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9697633/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of fungi (Basel, Switzerland)\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.3390/jof8111190\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of fungi (Basel, Switzerland)","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.3390/jof8111190","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Phaeosphaeridiols A-C: Three New Compounds from Undescribed Phaeosphaeriaceae sp. SGSF723.
Fungi in forest litter are diverse as decomposers but natural products from these fungi are rarely investigated, especially for their antimicrobial activities against crop diseases. In this study, fungal isolate SGSF723 with antimicrobial activities was cultured. A multi-gene phylogenetic analysis showed SGSF723 was an undescribed species in the family Phaeosphaeriaceae. By bio-guided assay, three new compounds (Phaeosphaeridiols A-C) and two known compounds were purified from the ethyl acetate extract. The structures of Phaeosphaeridiols A-C were elucidated as 2-(2'-butenyl)-5 (3″-pentene)-1,3-benzenediol (1), 2-(2'-butenyl)-5-(3″S,4″S-pentane diol)-1,3-benzenediol (2), and 3-(4'-(2″-butenyl)-3',5'-benzenediol phenol)-2-acrylic acid (3) by 2D NMR, HRESIMS, and Mosher's method. Phaeosphaeridiols A-C exhibited moderate or weak antimicrobial activities against plant pathogens by 96-well plate and spore germination assays.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
