[参与基因表达表观遗传调控的CXXC蛋白的相互作用组学]。

Q3 Biochemistry, Genetics and Molecular Biology
P V Ershov, E O Yablokov, Y V Mezentsev, A S Ivanov
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引用次数: 0

摘要

基因表达调控是一个极其复杂的多组分生物现象。含有cxxc结构域“锌指”的蛋白(cxxc蛋白)是许多基因表达的主要调控因子,具有DNA碱基和组蛋白甲基化的保守功能。CXXC蛋白作为多蛋白复合物的一部分发挥作用,这表明在正常和病理条件下通过调节蛋白相互作用谱(PPI)来研究翻译后调控的重要性。在本文中,我们从文献数据和我们自己的研究中讨论了CXXC蛋白及其蛋白伴侣参与肿瘤过程的一般方面。本文特别关注了位于人类18号染色体上的CXXC1基因编码的CFP1蛋白的特定相互作用组学的最新数据。CFP1缺乏酶活性,通过与染色质和一定谱的PPIs结合实现表观遗传表达调控。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Interactomics of CXXC proteins involved in epigenetic regulation of gene expression].

Regulation of gene expression is an extremely complex and multicomponent biological phenomenon. Proteins containing the CXXC-domain "zinc fingers" (CXXC-proteins) are master regulators of expression of many genes and have conserved functions of methylation of DNA bases and histone proteins. CXXC proteins function as a part of multiprotein complexes, which indicates the fundamental importance of studying post-translational regulation through modulation of the protein-protein interaction spectrum (PPI) in both normal and pathological conditions. In this paper we discuss general aspects of the involvement of CXXC proteins and their protein partners in neoplastic processes, both from the literature data and our own studies. Special attention is paid to recent data on the particular interactomics of the CFP1 protein encoded by the CXXC1 gene located on the human chromosome 18. CFP1 is devoid of enzymatic activity and implements epigenetic regulation of expression through binding to chromatin and a certain spectrum of PPIs.

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来源期刊
Biomeditsinskaya khimiya
Biomeditsinskaya khimiya Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)
CiteScore
1.30
自引率
0.00%
发文量
49
期刊介绍: The aim of the Russian-language journal "Biomeditsinskaya Khimiya" (Biomedical Chemistry) is to introduce the latest results obtained by scientists from Russia and other Republics of the Former Soviet Union. The Journal will cover all major areas of Biomedical chemistry, including neurochemistry, clinical chemistry, molecular biology of pathological processes, gene therapy, development of new drugs and their biochemical pharmacology, introduction and advertisement of new (biochemical) methods into experimental and clinical medicine etc. The Journal also publish review articles. All issues of journal usually contain invited reviews. Papers written in Russian contain abstract (in English).
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