硫化氢和新型供体治疗缺血性脑卒中的应用:叙述性回顾。

IF 3 Q2 MEDICINE, RESEARCH & EXPERIMENTAL
Jia-Sheng Ding, Yan Zhang, Tian-Yi Wang, Xiang Li, Cheng Ma, Zhong-Mou Xu, Qing Sun, Xiang Xu, Gang Chen
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引用次数: 4

摘要

缺血性脑卒中发生在脑供血受阻的情况下,与凋亡基因激活、氧化应激、炎症反应等多种复杂机制有关,最终导致神经功能障碍。有几种气体已被证明具有神经保护作用,即使是被认为有毒的经典气体,如硫化氢(H2S)。H2S是继一氧化碳和一氧化氮之后发现的第三种内源性气体信号分子。H2S在脑卒中中起重要作用。在体内和体外实验中,吸入H2S可以减轻大脑中动脉闭塞大鼠脑梗死体积,促进神经功能,从而减轻缺血性脑卒中损伤。因此,H2S在临床上可用于减轻缺血性脑卒中损伤。现就H2S对缺血性脑卒中的毒性机制及作用作一综述。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Therapeutic applications of hydrogen sulfide and novel donors for cerebral ischemic stroke: a narrative review.

Therapeutic applications of hydrogen sulfide and novel donors for cerebral ischemic stroke: a narrative review.

Ischemic stroke happens when the blood supply to the brain is obstructed and it is associated with numerous complex mechanisms, such as activated apoptosis genes, oxidative stress and reaction of inflammation, which finally result in neurological deficits. Several gases have been proved to have neuroprotective roles, even the classic gases that are thought to be toxic such as hydrogen sulfide (H2S). H2S is the third identified endogenous gas signaling molecule following carbon monoxide and nitric oxide. H2S plays a significant role in stroke. Inhalation of H2S can attenuate cerebral infarct volume and promote neurological function in a rat model of middle cerebral artery occlusion to reduce ischemic stroke-induced injury in vivo and in vitro as a result. Therefore, H2S can be clinically used to reduce ischemic stroke-induced injury. This review introduces the toxic mechanisms and effects of H2S on cerebral ischemic stroke.

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来源期刊
Medical Gas Research
Medical Gas Research MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
5.10
自引率
13.80%
发文量
35
期刊介绍: Medical Gas Research is an open access journal which publishes basic, translational, and clinical research focusing on the neurobiology as well as multidisciplinary aspects of medical gas research and their applications to related disorders. The journal covers all areas of medical gas research, but also has several special sections. Authors can submit directly to these sections, whose peer-review process is overseen by our distinguished Section Editors: Inert gases - Edited by Xuejun Sun and Mark Coburn, Gasotransmitters - Edited by Atsunori Nakao and John Calvert, Oxygen and diving medicine - Edited by Daniel Rossignol and Ke Jian Liu, Anesthetic gases - Edited by Richard Applegate and Zhongcong Xie, Medical gas in other fields of biology - Edited by John Zhang. Medical gas is a large family including oxygen, hydrogen, carbon monoxide, carbon dioxide, nitrogen, xenon, hydrogen sulfide, nitrous oxide, carbon disulfide, argon, helium and other noble gases. These medical gases are used in multiple fields of clinical practice and basic science research including anesthesiology, hyperbaric oxygen medicine, diving medicine, internal medicine, emergency medicine, surgery, and many basic sciences disciplines such as physiology, pharmacology, biochemistry, microbiology and neurosciences. Due to the unique nature of medical gas practice, Medical Gas Research will serve as an information platform for educational and technological advances in the field of medical gas.
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