冻融或温水油浸疫苗接种鸡的免疫反应。

IF 1.8 4区 农林科学 Q2 AGRICULTURE, DAIRY & ANIMAL SCIENCE
Takeshi Kawasaki, Tomohito Iwasaki, Takafumi Watanabe, Yasuhiro Hasegawa, Marina Hosotani, Michi Yamada
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引用次数: 0

摘要

本研究考察了冷冻或加热油包水(W/O)疫苗是否会影响鸡的免疫反应。影响市售动物疫苗效力的条件之一是储存温度范围。以往的研究表明,某些灭活疫苗的性质因冷冻而发生变化,导致接种后免疫反应性降低。在这项研究中,我们首先使用保持在-10、-13、-15和-20°C的冰柜确定了商用W/O疫苗的冷冻温度。结果表明,W/O疫苗在-10 ~ -12℃冻结。接下来,我们评估了接种W/O疫苗的46日龄肉鸡在-20°C、5°C和-10°C环境下抗体水平转变(样本阳性比)的影响。此外,对接种了W/O疫苗的45日龄肉鸡,在-20°C ~ 5°C之间反复冻融或加热至45°C,评估了其对抗体值转换的影响。在这些实验中,没有观察到冻融或加热处理对抗体值转变的显著影响。这些结果表明,将W/O疫苗置于冷冻环境或在42°C或更低的室温环境中放置约5天,对其效力没有明显影响。这些数据表明,有可能扩大处理W/O疫苗的温度范围。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Immune Response in Chickens Vaccinated with Freeze-Thawed or Warmed Water-in-Oil Vaccine.

Immune Response in Chickens Vaccinated with Freeze-Thawed or Warmed Water-in-Oil Vaccine.

Immune Response in Chickens Vaccinated with Freeze-Thawed or Warmed Water-in-Oil Vaccine.

This study investigated whether freezing or warming water-in-oil (W/O) vaccines affected the immune responses of chickens. One of the conditions affecting the efficacy of commercially available animal vaccines is the storage temperature range. Previous studies have shown that the properties of some inactivated vaccines change owing to freezing, leading to reduced immune responsiveness after inoculation. In this study, we first determined the freezing temperatures of a commercial W/O vaccine using freezers maintained at -10, -13, -15, and -20°C. The results showed that the W/O vaccine froze from -10 to -12°C. Next, we evaluated the effect on antibody level transitions (sample-to-positive ratio) in 46-day-old broiler chickens vaccinated with the W/O vaccine that was maintained at -20°C, 5°C, and -10°C, in that order. In addition, the effect on antibody value transitions was evaluated in 45-day-old broiler chickens vaccinated with the W/O vaccines that were frozen and thawed between -20°C and 5°C repeatedly or warmed to 45°C. In these experiments, no remarkable effect of the freeze-thawing or warming treatments on antibody value transitions was observed. These results suggested that the efficacy of the W/O vaccine was not significantly affected when placed in a frozen environment or left in a room temperature environment of 42°C or lower for approximately 5 d. These data indicate the possibility of expanding the temperature range for handling W/O vaccines.

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来源期刊
Journal of Poultry Science
Journal of Poultry Science AGRICULTURE, DAIRY & ANIMAL SCIENCE-
CiteScore
2.80
自引率
13.30%
发文量
26
审稿时长
12 months
期刊介绍: The Journal of Poultry Science will publish original reports and reviews which either make an original contribution to fundamental science or are of obvious application to the industry. Subjects which are covered include: breeding and genetics, nutrition and feeds, physiology, reproduction, immunology, behavior, environmental science, management and housing welfare, processing and products, and health in poultry. Submission of original articles to the Journal is open to all poultry researchers. The review articles are invited papers written by international outstanding researchers. Articles will be published in English, American style.
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