{"title":"山茶醇提物对柏氏疟原虫感染的糖尿病小鼠具有降糖作用，但缺乏抗疟作用。","authors":"Mufliat Temitope Akinwunmi, Rahmat Adetutu Adisa, Shamusideen Olusegun Aroyeun, Olusegun George Ademowo","doi":"10.54548/njps.v36i2.7","DOIUrl":null,"url":null,"abstract":"<p><p>The in vivo antimalarial and antidiabetic activity of extract of Camellia sinensis (ECS) in alloxan-induced diabetic and Plasmodium berghei-infected mice were investigated. Eighty-four BALB/c mice divided into sets 1 & 2 infected with P. berghei and 2 & 3 injected with alloxan received either distilled water, ECS (300mg/kg), Chloroquine (CQ-10mg/kg) or Metformin (250mg/kg). Results showed significant increases (p<0.05) in percentage parasitaemia of P. berghei-infected mice treated with ECS and P. berghei-diabetic mice. Furthermore, ECS significantly decreased (p<0.05) blood glucose and PCV in diabetic and P. berghei-diabetic mice. ECS regenerated pancreatic islet cells in P. berghei-infected-diabetes but lacked appreciable antimalarial activity.</p>","PeriodicalId":35043,"journal":{"name":"Nigerian Journal of Physiological Sciences","volume":"36 2","pages":"189-194"},"PeriodicalIF":0.0000,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Ethanolic extract of Camellia sinensise licited hypoglycemic but lacked antimalarial properties in Plasmodium berghei-infected diabetic mice.\",\"authors\":\"Mufliat Temitope Akinwunmi, Rahmat Adetutu Adisa, Shamusideen Olusegun Aroyeun, Olusegun George Ademowo\",\"doi\":\"10.54548/njps.v36i2.7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The in vivo antimalarial and antidiabetic activity of extract of Camellia sinensis (ECS) in alloxan-induced diabetic and Plasmodium berghei-infected mice were investigated. Eighty-four BALB/c mice divided into sets 1 & 2 infected with P. berghei and 2 & 3 injected with alloxan received either distilled water, ECS (300mg/kg), Chloroquine (CQ-10mg/kg) or Metformin (250mg/kg). Results showed significant increases (p<0.05) in percentage parasitaemia of P. berghei-infected mice treated with ECS and P. berghei-diabetic mice. Furthermore, ECS significantly decreased (p<0.05) blood glucose and PCV in diabetic and P. berghei-diabetic mice. ECS regenerated pancreatic islet cells in P. berghei-infected-diabetes but lacked appreciable antimalarial activity.</p>\",\"PeriodicalId\":35043,\"journal\":{\"name\":\"Nigerian Journal of Physiological Sciences\",\"volume\":\"36 2\",\"pages\":\"189-194\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-12-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nigerian Journal of Physiological Sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.54548/njps.v36i2.7\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nigerian Journal of Physiological Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.54548/njps.v36i2.7","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
Ethanolic extract of Camellia sinensise licited hypoglycemic but lacked antimalarial properties in Plasmodium berghei-infected diabetic mice.
The in vivo antimalarial and antidiabetic activity of extract of Camellia sinensis (ECS) in alloxan-induced diabetic and Plasmodium berghei-infected mice were investigated. Eighty-four BALB/c mice divided into sets 1 & 2 infected with P. berghei and 2 & 3 injected with alloxan received either distilled water, ECS (300mg/kg), Chloroquine (CQ-10mg/kg) or Metformin (250mg/kg). Results showed significant increases (p<0.05) in percentage parasitaemia of P. berghei-infected mice treated with ECS and P. berghei-diabetic mice. Furthermore, ECS significantly decreased (p<0.05) blood glucose and PCV in diabetic and P. berghei-diabetic mice. ECS regenerated pancreatic islet cells in P. berghei-infected-diabetes but lacked appreciable antimalarial activity.
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