牛磺酸烷对毛霉的抗真菌活性:临床分离物的体外研究。

Q3 Medicine
Hadis Jafarian, Ali Amanati, Parisa Badiee
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引用次数: 0

摘要

背景与目的:牛磺酸对多种微生物有活性,包括细菌和真菌。毛霉病是危及生命的机会性真菌感染之一,特别是在免疫功能低下的患者中。目前,在COVID-19大流行期间出现的毛霉菌病引起了公众对SARS-CoV-2患者发病率和死亡率的担忧。众所周知,延迟和不适当的抗真菌治疗导致发病率和死亡率增加。本研究旨在研究牛磺酸醚的体外抑菌活性,以评价其对临床分离的毛霉菌的抑菌效果。材料和方法:本研究包括先前收集的临床毛霉菌分离株。采用肉汤微量稀释法测定两性霉素B、卡泊芬净、伏立康唑、泊沙康唑和伊曲康唑的最小体外抑制浓度(MIC)。结果:所有临床分离株对两性霉素b均完全敏感,泊沙康唑的MIC范围为8 ~ 0.032 μg/mL。测定伏立康唑和卡泊芬净的MIC范围分别为2 ~ 8µg/mL和0.5 ~ 16µg/mL。在1000µg/mL的牛磺酸浓度下,菌株的生长完全被抑制。在显微镜下观察,500µg/mL浓度对菌丝生长的形态学影响。结论:本研究总结了牛罗列丁对毛霉菌的最新应用经验。然而,我们的体外研究结果需要在旨在治疗侵袭性毛霉感染的精心设计的临床试验中得到证实。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Antifungal activity of Taurolidine against Mucorales: An in vitro study on clinical isolates.

Antifungal activity of Taurolidine against Mucorales: An in vitro study on clinical isolates.

Antifungal activity of Taurolidine against Mucorales: An in vitro study on clinical isolates.

Antifungal activity of Taurolidine against Mucorales: An in vitro study on clinical isolates.

Background and purpose: Taurolidine is active against a wide variety of micro-organisms, including bacteria and fungi. Mucormycosis is one of the life-threatening opportunistic fungal infections, especially in immunocompromised patients. Currently, the emergence of Mucormycosis during the COVID-19 pandemic raises public health concerns regarding untoward morbidity and mortality among SARS-CoV-2 patients. It is well-known that delayed and inappropriate antifungal therapy leads to increased morbidity and mortality. This study aimed to investigate the in-vitro antifungal activity of taurolidine to evaluate its effects against clinical isolates of Mucorales.

Materials and methods: This study included previously collected clinical Mucorales isolates. The minimum in vitro inhibitory concentration (MIC) of amphotericin B, caspofungin, voriconazole, posaconazole, and itraconazole was determined using the broth microdilution method.

Results: All clinical isolates showed full sensitivity to amphotericin B. Posaconazole MIC range from 8 μg/mL to 0.032‎ μg/mL. The MIC range of voriconazole and caspofungin were determined to be 2-8 µg/mL and 0.5-16 µg/mL, respectively. Growth of the isolates was entirely inhibited in 1000 µg/mL concentration of taurolidine. In microscopic observations, morphological effects on hyphal growth were observed at 500 µg/mL concentration.

Conclusion: In conclusion, this is an updated experience of using taurolidine against Mucorales. However, our in-vitro findings need to be confirmed in well-designed clinical trials aimed at treating invasive Mucormycosis infections.

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来源期刊
Current Medical Mycology
Current Medical Mycology Medicine-Infectious Diseases
CiteScore
2.10
自引率
0.00%
发文量
16
审稿时长
4 weeks
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