心室周围器官中的小胶质细胞:松果体的例子。

IF 3.7 4区 医学 Q2 NEUROSCIENCES
Estela M Muñoz
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引用次数: 2

摘要

心室周围器官(CVOs)是中枢神经系统中独特的区域。它们作为身体其他部分的入口,因此缺乏血脑屏障。小胶质细胞是脑实质的主要常驻免疫细胞。在CVOs内,小胶质细胞发现自己不断受到局部和全身刺激的挑战和刺激,即使在稳态条件下也是如此。因此,典型状态下的CVO小胶质细胞在对病理条件或其他压力源作出反应时,往往与大脑其他地方发现的活化小胶质细胞形式相似。在这篇综述中,我着重于CVO小胶质细胞的动力学,以松果体作为CVO的具体例子。介绍和讨论了在稳态和不健康环境中与小胶质细胞异质性相关的数据,包括最近使用先进的单细胞和单核技术产生的数据。最后,在CVO小胶质细胞领域的观点也包括在内。心室周围器官(CVOs)中的小胶质细胞不断适应以对它们面临的各种挑战做出不同的反应。本文讨论了包括松果体在内的CVOs的小胶质细胞异质性。需要进一步的研究来更好地了解这些独特脑区的小胶质细胞动力学。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Microglia in Circumventricular Organs: The Pineal Gland Example.

Microglia in Circumventricular Organs: The Pineal Gland Example.

Microglia in Circumventricular Organs: The Pineal Gland Example.

Microglia in Circumventricular Organs: The Pineal Gland Example.

The circumventricular organs (CVOs) are unique areas within the central nervous system. They serve as a portal for the rest of the body and, as such, lack a blood-brain barrier. Microglia are the primary resident immune cells of the brain parenchyma. Within the CVOs, microglial cells find themselves continuously challenged and stimulated by local and systemic stimuli, even under steady-state conditions. Therefore, CVO microglia in their typical state often resemble the activated microglial forms found elsewhere in the brain as they are responding to pathological conditions or other stressors. In this review, I focus on the dynamics of CVO microglia, using the pineal gland as a specific CVO example. Data related to microglia heterogeneity in both homeostatic and unhealthy environments are presented and discussed, including those recently generated by using advanced single-cell and single-nucleus technology. Finally, perspectives in the CVO microglia field are also included.Summary StatementMicroglia in circumventricular organs (CVOs) continuously adapt to react differentially to the diverse challenges they face. Herein, I discuss microglia heterogeneity in CVOs, including pineal gland. Further studies are needed to better understand microglia dynamics in these unique brain areas. .

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来源期刊
ASN NEURO
ASN NEURO NEUROSCIENCES-
CiteScore
7.70
自引率
4.30%
发文量
35
审稿时长
>12 weeks
期刊介绍: ASN NEURO is an open access, peer-reviewed journal uniquely positioned to provide investigators with the most recent advances across the breadth of the cellular and molecular neurosciences. The official journal of the American Society for Neurochemistry, ASN NEURO is dedicated to the promotion, support, and facilitation of communication among cellular and molecular neuroscientists of all specializations.
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