残胃癌的肿瘤部位导致不同的复发方式。

IF 3.2 4区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
Bo Sun, Haixian Zhang, Jiangli Wang, Hong Cai, Yi Xuan, Dazhi Xu
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引用次数: 0

摘要

目的:肿瘤复发是残胃癌(RGC)术后预后不良的主要原因。我们试图根据RGC的肿瘤位置阐明复发模式。材料和方法:数据收集于2006年1月至2020年12月在上海癌症中心。本研究共纳入129例RGC患者,其中吻合口癌62例(A组),非吻合口癌67例(N组)。根据肿瘤部位调查临床病理特征、手术结果、复发情况及生存期。结果:A组和N组从既往胃切除术到本次诊断的时间间隔分别为32.0±13.0年和21.0±13.4年。A组既往病变51/62例(82.3%)为良性,N组37/67例(55.2%)为良性(P=0.002)。33例患者经影像学或病理检查发现肿瘤复发部位。中位复发时间为11.0个月(范围1.0-35.1个月)。A组患者腹膜复发率为11.3% (7/62),N组为1.5% (1/67)(P=0.006)。A组患者肝脏复发率为3.2% (2/62),N组为13.4% (9/67)(P=0.038)。A组患者总生存率显著高于N组(P=0.046)。结论:RGC的肿瘤位置是预测复发方式和总生存率的重要因素。在选择最佳的RGC术后随访方案时,医生应根据肿瘤位置考虑复发特征。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Tumor Location Causes Different Recurrence Patterns in Remnant Gastric Cancer.

Tumor Location Causes Different Recurrence Patterns in Remnant Gastric Cancer.

Tumor Location Causes Different Recurrence Patterns in Remnant Gastric Cancer.

Tumor Location Causes Different Recurrence Patterns in Remnant Gastric Cancer.

Purpose: Tumor recurrence is the principal cause of poor outcomes in remnant gastric cancer (RGC) after resection. We sought to elucidate the recurrent patterns according to tumor locations in RGC.

Materials and methods: Data were collected from the Shanghai Cancer Center between January 2006 and December 2020. A total of 129 patients with RGC were included in this study, of whom 62 had carcinomas at the anastomotic site (group A) and 67 at the non-anastomotic site (group N). The clinicopathological characteristics, surgical results, recurrent diseases, and survival were investigated according to tumor location.

Results: The time interval from the previous gastrectomy to the current diagnosis was 32.0±13.0 and 21.0±13.4 years in groups A and N, respectively. The previous disease was benign in 51/62 cases (82.3%) in group A and 37/67 cases (55.2%) in group N (P=0.002). Thirty-three patients had documented sites of tumor recurrence through imaging or pathological examinations. The median time to recurrence was 11.0 months (range, 1.0-35.1 months). Peritoneal recurrence occurred in 11.3% (7/62) of the patients in group A versus 1.5% (1/67) of the patients in group N (P=0.006). Hepatic recurrence occurred in 3.2% (2/62) of the patients in group A versus 13.4% (9/67) of the patients in group N (P=0.038). Patients in group A had significantly better overall survival than those in group N (P=0.046).

Conclusions: The tumor location of RGC is an essential factor for predicting recurrence patterns and overall survival. When selecting an optimal postoperative follow-up program for RGC, physicians should consider recurrent features according to the tumor location.

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来源期刊
Journal of Gastric Cancer
Journal of Gastric Cancer Biochemistry, Genetics and Molecular Biology-Cancer Research
CiteScore
4.30
自引率
12.00%
发文量
36
期刊介绍: The Journal of Gastric Cancer (J Gastric Cancer) is an international peer-reviewed journal. Each issue carries high quality clinical and translational researches on gastric neoplasms. Editorial Board of J Gastric Cancer publishes original articles on pathophysiology, molecular oncology, diagnosis, treatment, and prevention of gastric cancer as well as articles on dietary control and improving the quality of life for gastric cancer patients. J Gastric Cancer includes case reports, review articles, how I do it articles, editorials, and letters to the editor.
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