血清血管紧张素转换酶在矽肺病中的临床应用。

IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM
J. Blanco-Pérez , Á. Salgado-Barreira , S. Blanco-Dorado , M.E. González Bello , A.C. Caldera Díaz , A. Pérez-Gonzalez , A. Pallarés Sanmartín , A. Fernández Villar , F.J. Gonzalez-Barcala
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引用次数: 0

摘要

导言矽肺病是一种不可逆转、无法治愈的疾病。消除接触的预防措施是降低发病率和死亡率的唯一有效方法。在这种情况下,如果能有一种生物标志物用于早期诊断或预测病情发展,将对改善疾病控制非常有用。目的:确定暴露于二氧化硅粉尘并患有和未患有矽肺病的一组患者的血清血管紧张素转换酶(sACE)水平,并评估其对上述患者预后的影响:对 2009 年至 2018 年期间在矽肺诊所接受治疗的患者进行前瞻性观察研究。自纳入研究时起,对已进行过 2 次胸部 X 光检查和/或 2 次 CT 扫描且间隔至少 1 年的患者进行放射学进展评估:共有 413 例矽肺患者得到确诊,另有 73 例患者接触过矽尘但未患矽肺。健康受试者的平均 sACE 水平为(27.5±7.3)U/L,无矽肺的暴露患者的平均 sACE 水平为(49.6±24.2)U/L,单纯性矽肺患者的平均 sACE 水平为(57.8±31.3)U/L,复杂性矽肺患者的平均 sACE 水平为(74.5±38.6)U/L。在随访期间,sACE 较高的患者一般在放射学上有所进展(73.3±38.0 vs. 60.4±33.7;p 结论:矽肺患者的 sACE 升高,且严重程度越高,sACE 越高,这与放射学上测量的疾病进展或矽肺类别变化有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Clinical usefulness of serum angiotensin converting enzyme in silicosis

Introduction

Silicosis is an irreversible and incurable disease. Preventive measures to eliminate exposure are the only effective way to reduce morbidity and mortality. In such situations, having a biomarker for early diagnosis or to predict evolution would be very useful in order to improve control of the disease. The elevation of serum angiotensin-converting enzyme (sACE) in silicosis has been described in previous studies, although its relationship with severity and prognosis is not clear.

Aims

To determine the levels of sACE in a cohort of patients with exposure to silica dust with and without silicosis, and to assess their impact on the prognosis of the aforementioned patients.

Method

Prospective observational study on patients treated in a silicosis clinic from 2009 to 2018. sACE levels and pulmonary function tests were performed. Radiological progression was assessed in patients who had already had 2 X-rays of the thorax and / or two CT scans with at least a 1-year interval, from the time of inclusion in the study.

Results

A total of 413 cases of silicosis were confirmed, as well as 73 with exposure to silica dust but without silicosis. The mean sACE level for healthy subjects was 27.5±7.3U/L, for exposed patients without silicosis it was 49.6±24.2U/L, for simple silicosis it was 57.8±31,3U/L and for complicated silicosis it was 74.5±38.6U/L. Patients with a higher sACE generally progressed radiologically during follow-up (73.3±38.0 vs. 60.4±33.7; p<.001) and so the category of silicosis changed (73,9±38.1 vs. 62.5±34.6; p<.021).

Conclusions

sACE was elevated in patients with silicosis, and the greater its severity, the higher it was, which is associated with disease progression measured radiologically or as a category change of silicosis.

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来源期刊
Pulmonology
Pulmonology Medicine-Pulmonary and Respiratory Medicine
CiteScore
14.30
自引率
5.10%
发文量
159
审稿时长
19 days
期刊介绍: Pulmonology (previously Revista Portuguesa de Pneumologia) is the official journal of the Portuguese Society of Pulmonology (Sociedade Portuguesa de Pneumologia/SPP). The journal publishes 6 issues per year and focuses on respiratory system diseases in adults and clinical research. It accepts various types of articles including peer-reviewed original articles, review articles, editorials, and opinion articles. The journal is published in English and is freely accessible through its website, as well as Medline and other databases. It is indexed in Science Citation Index Expanded, Journal of Citation Reports, Index Medicus/MEDLINE, Scopus, and EMBASE/Excerpta Medica.
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