Seong Hwan Kim, Ju-Mi Lee, Seung Ku Lee, Chol Shin, Jae-Hyeong Park
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Latent mixture modeling was used to identify trajectories in mid-BP ((systolic BP + diastolic BP)/2) over time. Linear logistic regression was used for assessing BP trajectories with the outcomes.</p><p><strong>Results: </strong>We identified 4 distinct mid-BP trajectories: group 1 (lowest, 20.9%, <i>n</i> = 536), group 2 (36.2%, <i>n</i> = 928), group 3 (32.3%, <i>n</i> = 828), and group 4 (highest, 10.6%, <i>n</i> = 273). Compared with the lowest group, trajectories with elevated mid-BP had greater odds ratios having LVH and LAE by multivariable-adjusted regression models. Adjusted odd ratios for LVH were 2.033 (95% CI = 1.462-2.827, <i>P</i> < 0.001) for group 2, 3.446 (95% CI = 2.475-4.797, <i>P</i> < 0.001) for group 3, and 4.940 (95% CI = 3.318-7.356, <i>P</i> < 0.001) for group 4. Adjusted odd ratios for LAE were 1.200 (95% CI = 0.814-1.769, <i>P</i> = 0.358) for group 2, 1.599 (95% CI = 1.084-2.360, <i>P</i> = 0.018) for group 3, and 1.944 (95% CI = 1.212-3.118, <i>P</i> = 0.006) for group 4.</p><p><strong>Conclusions: </strong>Higher long-term mid-BP was an independent risk factor of cardiac structural changes such as LVH and LAE among middle-aged population.</p>","PeriodicalId":14132,"journal":{"name":"International Journal of Hypertension","volume":" ","pages":"6750317"},"PeriodicalIF":1.9000,"publicationDate":"2022-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313986/pdf/","citationCount":"3","resultStr":"{\"title\":\"Blood Pressure Trajectories for 16 Years and the Development of Left Ventricular Hypertrophy and Increased Left Atrial Size: The Korean Genome and Epidemiology Study.\",\"authors\":\"Seong Hwan Kim, Ju-Mi Lee, Seung Ku Lee, Chol Shin, Jae-Hyeong Park\",\"doi\":\"10.1155/2022/6750317\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Elevated single blood pressure (BP) measurement can be associated with the development of hypertension-mediated target organ damage including left ventricular hypertrophy (LVH) and left atrial (LA) enlargement (LAE). However, long-term patterns of BP and their effects on LVH and LAE are poorly understood. We evaluated the association between the BP trajectories and the presence of LVH and LAE.</p><p><strong>Methods: </strong>We analyzed a total of 2,565 participants (1,267 males, 47.8 ± 6.7 years old) from the first biennial examination (2001-2002) of the Korean Genome and Epidemiology Study. The presence of LVH and LAE was identified by echocardiography performed at the 8<sup>th</sup> biennial examination (2015-2016). Latent mixture modeling was used to identify trajectories in mid-BP ((systolic BP + diastolic BP)/2) over time. Linear logistic regression was used for assessing BP trajectories with the outcomes.</p><p><strong>Results: </strong>We identified 4 distinct mid-BP trajectories: group 1 (lowest, 20.9%, <i>n</i> = 536), group 2 (36.2%, <i>n</i> = 928), group 3 (32.3%, <i>n</i> = 828), and group 4 (highest, 10.6%, <i>n</i> = 273). 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引用次数: 3
摘要
背景:单次血压(BP)测量升高可能与高血压介导的靶器官损害的发展有关，包括左心室肥厚(LVH)和左心房(LA)扩大(LAE)。然而，BP的长期模式及其对LVH和LAE的影响尚不清楚。我们评估了血压轨迹与LVH和LAE存在之间的关系。方法:我们分析了2001-2002年韩国基因组与流行病学研究第一次两年一次检查的2565名参与者(男性1267人，47.8±6.7岁)。在第8次两年一次的检查(2015-2016)中通过超声心动图确定LVH和LAE的存在。潜在混合模型用于识别中BP((收缩压+舒张压)/2)随时间的变化轨迹。线性逻辑回归用于评估BP轨迹与结果。结果:我们确定了4种不同的中期血压轨迹:组1(最低，20.9%，n = 536)，组2 (36.2%，n = 928)，组3 (32.3%，n = 828)和组4(最高，10.6%，n = 273)。通过多变量调整回归模型，与最低血压组相比，中血压升高的轨迹具有更大的LVH和LAE的比值比。第2组LVH的校正奇比为2.033 (95% CI = 1.462-2.827, P < 0.001)，第3组为3.446 (95% CI = 2.475-4.797, P < 0.001)，第4组为4.940 (95% CI = 3.318-7.356, P < 0.001)。2组LAE的调整奇数比为1.200 (95% CI = 0.814-1.769, P = 0.358)， 3组为1.599 (95% CI = 1.084-2.360, P = 0.018)， 4组为1.944 (95% CI = 1.212-3.118, P = 0.006)。结论:中程长期血压升高是中年人群LVH、LAE等心脏结构改变的独立危险因素。
Blood Pressure Trajectories for 16 Years and the Development of Left Ventricular Hypertrophy and Increased Left Atrial Size: The Korean Genome and Epidemiology Study.
Background: Elevated single blood pressure (BP) measurement can be associated with the development of hypertension-mediated target organ damage including left ventricular hypertrophy (LVH) and left atrial (LA) enlargement (LAE). However, long-term patterns of BP and their effects on LVH and LAE are poorly understood. We evaluated the association between the BP trajectories and the presence of LVH and LAE.
Methods: We analyzed a total of 2,565 participants (1,267 males, 47.8 ± 6.7 years old) from the first biennial examination (2001-2002) of the Korean Genome and Epidemiology Study. The presence of LVH and LAE was identified by echocardiography performed at the 8th biennial examination (2015-2016). Latent mixture modeling was used to identify trajectories in mid-BP ((systolic BP + diastolic BP)/2) over time. Linear logistic regression was used for assessing BP trajectories with the outcomes.
Results: We identified 4 distinct mid-BP trajectories: group 1 (lowest, 20.9%, n = 536), group 2 (36.2%, n = 928), group 3 (32.3%, n = 828), and group 4 (highest, 10.6%, n = 273). Compared with the lowest group, trajectories with elevated mid-BP had greater odds ratios having LVH and LAE by multivariable-adjusted regression models. Adjusted odd ratios for LVH were 2.033 (95% CI = 1.462-2.827, P < 0.001) for group 2, 3.446 (95% CI = 2.475-4.797, P < 0.001) for group 3, and 4.940 (95% CI = 3.318-7.356, P < 0.001) for group 4. Adjusted odd ratios for LAE were 1.200 (95% CI = 0.814-1.769, P = 0.358) for group 2, 1.599 (95% CI = 1.084-2.360, P = 0.018) for group 3, and 1.944 (95% CI = 1.212-3.118, P = 0.006) for group 4.
Conclusions: Higher long-term mid-BP was an independent risk factor of cardiac structural changes such as LVH and LAE among middle-aged population.
期刊介绍：
International Journal of Hypertension is a peer-reviewed, Open Access journal that provides a forum for clinicians and basic scientists interested in blood pressure regulation and pathophysiology, as well as treatment and prevention of hypertension. The journal publishes original research articles, review articles, and clinical studies on the etiology and risk factors of hypertension, with a special focus on vascular biology, epidemiology, pediatric hypertension, and hypertensive nephropathy.
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