{"title":"急性缺血性脑卒中后脑水肿的精准治疗。","authors":"Simiao Wu, Craig S Anderson","doi":"10.1093/pcmedi/pbac019","DOIUrl":null,"url":null,"abstract":"Stroke is a leading cause of death and disability in the world, with acute ischaemic stroke accounting for ∼ 70% of all cases. 1 Some degree of brain oedema occurs in all cases of acute ischaemic stroke and, when severe, has major consequences on survival-free of disability. Pathophysiological studies indicate an evolu-tion of cytotoxic oedema, ionic oedema, and vasogenic oedema, 2 which implies brain oedema is a dynamic process and explains the various terminology used, such as large hemispheric infarc-tion,symptomatic infarct swelling,space-occupying infarction,or malignant middle cerebral artery (MCA) infarction . Heterogene-ity in manifestations and sequelae necessitates a new, precision medicine approach to individualizing prevention and treatment of brain oedema after stroke.","PeriodicalId":33608,"journal":{"name":"Precision Clinical Medicine","volume":null,"pages":null},"PeriodicalIF":5.1000,"publicationDate":"2022-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9384835/pdf/","citationCount":"2","resultStr":"{\"title\":\"Precision management of brain oedema after acute ischaemic stroke.\",\"authors\":\"Simiao Wu, Craig S Anderson\",\"doi\":\"10.1093/pcmedi/pbac019\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Stroke is a leading cause of death and disability in the world, with acute ischaemic stroke accounting for ∼ 70% of all cases. 1 Some degree of brain oedema occurs in all cases of acute ischaemic stroke and, when severe, has major consequences on survival-free of disability. Pathophysiological studies indicate an evolu-tion of cytotoxic oedema, ionic oedema, and vasogenic oedema, 2 which implies brain oedema is a dynamic process and explains the various terminology used, such as large hemispheric infarc-tion,symptomatic infarct swelling,space-occupying infarction,or malignant middle cerebral artery (MCA) infarction . Heterogene-ity in manifestations and sequelae necessitates a new, precision medicine approach to individualizing prevention and treatment of brain oedema after stroke.\",\"PeriodicalId\":33608,\"journal\":{\"name\":\"Precision Clinical Medicine\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":5.1000,\"publicationDate\":\"2022-07-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9384835/pdf/\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Precision Clinical Medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1093/pcmedi/pbac019\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2022/9/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q1\",\"JCRName\":\"MEDICINE, RESEARCH & EXPERIMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Precision Clinical Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/pcmedi/pbac019","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/9/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
Precision management of brain oedema after acute ischaemic stroke.
Stroke is a leading cause of death and disability in the world, with acute ischaemic stroke accounting for ∼ 70% of all cases. 1 Some degree of brain oedema occurs in all cases of acute ischaemic stroke and, when severe, has major consequences on survival-free of disability. Pathophysiological studies indicate an evolu-tion of cytotoxic oedema, ionic oedema, and vasogenic oedema, 2 which implies brain oedema is a dynamic process and explains the various terminology used, such as large hemispheric infarc-tion,symptomatic infarct swelling,space-occupying infarction,or malignant middle cerebral artery (MCA) infarction . Heterogene-ity in manifestations and sequelae necessitates a new, precision medicine approach to individualizing prevention and treatment of brain oedema after stroke.
期刊介绍:
Precision Clinical Medicine (PCM) is an international, peer-reviewed, open access journal that provides timely publication of original research articles, case reports, reviews, editorials, and perspectives across the spectrum of precision medicine. The journal's mission is to deliver new theories, methods, and evidence that enhance disease diagnosis, treatment, prevention, and prognosis, thereby establishing a vital communication platform for clinicians and researchers that has the potential to transform medical practice. PCM encompasses all facets of precision medicine, which involves personalized approaches to diagnosis, treatment, and prevention, tailored to individual patients or patient subgroups based on their unique genetic, phenotypic, or psychosocial profiles. The clinical conditions addressed by the journal include a wide range of areas such as cancer, infectious diseases, inherited diseases, complex diseases, and rare diseases.