eaat1依赖性slc1a3转录控制依赖于底物易位过程。

IF 3.9 4区医学 Q2 NEUROSCIENCES

ASN NEURO Pub Date : 2022-01-01 DOI:10.1177/17590914221116574

Dinorah Hernández-Melchor, Leticia Ramírez-Martínez, Luis Cid, Cecilia Palafox-Gómez, Esther López-Bayghen, Arturo Ortega

引用次数: 1

摘要

摘要:EAAT1/GLAST通过激活包括PI3K、PKC和NF-κB在内的信号通路，在转录水平下调其表达和功能，支持谷氨酸再循环及其通过胶质细胞突触交易的活性依赖微调的概念。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

EAAT1-dependent <i>slc1a3</i> Transcriptional Control depends on the Substrate Translocation Process.

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EAAT1-dependent slc1a3 Transcriptional Control depends on the Substrate Translocation Process.

Summary statement: EAAT1/GLAST down-regulates its expression and function at the transcriptional level by activating a signaling pathway that includes PI3K, PKC and NF-κB, favoring the notion of an activity-dependent fine-tuning of glutamate recycling and its synaptic transactions through glial cells.

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来源期刊

ASN NEURO NEUROSCIENCES-

CiteScore

7.70

自引率

4.30%

发文量

审稿时长

>12 weeks

期刊介绍： ASN NEURO is an open access, peer-reviewed journal uniquely positioned to provide investigators with the most recent advances across the breadth of the cellular and molecular neurosciences. The official journal of the American Society for Neurochemistry, ASN NEURO is dedicated to the promotion, support, and facilitation of communication among cellular and molecular neuroscientists of all specializations.