系统性红斑狼疮患者的动脉僵硬和动脉粥样硬化。

IF 1.4 Q3 RHEUMATOLOGY
Reumatologia Pub Date : 2022-01-01 Epub Date: 2022-07-13 DOI:10.5114/reum.2022.117836
Hanna Dziedzic-Oleksy, Adam Mazurek, Kamil Bugała, Carlo Perricone, Leszek Drabik, Wojciech Płazak
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引用次数: 2

摘要

系统性红斑狼疮(SLE)以早期动脉粥样硬化血栓形成为特征。脉搏波速度(PWV)是诊断早期血管重构和动脉粥样硬化斑块形成的一种很有前途的工具。我们的目的是评估SLE患者的PWV及其与冠状动脉粥样硬化和血栓形成生物标志物的关系。材料与方法:对26例临床状况稳定、平均年龄39.1±11.7岁、无冠状动脉疾病史的SLE患者进行基于多探测器计算机断层扫描(MDCT)的冠状动脉钙化评分(CACS)并测量PWV。实验室评估包括血清抗心磷脂和抗β2-糖蛋白抗体(anti-β2-GPI)、狼疮抗凝血剂(LA)、d -二聚体、凝血酶-抗凝血酶复合物(TAT)和血管性血友病因子(vWF)水平。结果:多探测器计算机断层扫描显示8例(30.8%)患者冠状动脉钙化,中位CACS为52.4 HU(范围2-843.2)。平均PWV为9.0±3.2 m/s,年龄> 50岁(+33.7% vs. < 50岁)、LA阳性(+28.2% vs. LA阴性)、TAT≥10 μg/l (+18.1% vs. < 10 μg/l)、vWF≥200 IU/dl (+51.8% vs. < 200 IU/dl)、冠状动脉粥样硬化(CACS > 0;相比之下,病程、d -二聚体、抗心磷脂和抗β2- gpi抗体对PWV没有影响。在无动脉粥样硬化组(CACS = 0, n =18)中,vWF≥200 IU/dl的患者的PWV比其他患者高19.3%。结论:在SLE患者中,PWV与MDCT中冠状动脉粥样硬化病变的存在有关。此外,在内皮功能障碍和血栓前状态的患者中,动脉僵硬度更高,这表明它们对SLE早期动脉重构的贡献。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Arterial stiffness and atherosclerosis in systemic lupus erythematosus patients.

Arterial stiffness and atherosclerosis in systemic lupus erythematosus patients.

Arterial stiffness and atherosclerosis in systemic lupus erythematosus patients.
Introduction Systemic lupus erythematosus (SLE) is characterized by early atherothrombosis. Pulse wave velocity (PWV) is a promising tool for the diagnosis of early vascular remodelling and initial atherosclerotic plaque formation. Our objective was to evaluate PWV and its relationship with coronary atherosclerosis and thrombotic biomarkers in patients with SLE. Material and methods In 26 patients with SLE with stable clinical conditions, mean age of 39.1 ±11.7 years and without a history of coronary artery disease, multidetector computed tomography (MDCT)-based coronary calcium scoring (CACS) was performed and PWV measured. Laboratory evaluation included serum levels of anticardiolipin and anti-β2-glycoprotein antibodies (anti-β2-GPI), lupus anticoagulant (LA), D-dimers, thrombin–antithrombin complexes (TAT), and von Willebrand factor (vWF). Results Multidetector computed tomography revealed coronary calcifications in 8 (30.8%) patients and the median CACS was 52.4 HU (range 2–843.2). The mean PWV was 9.0 ±3.2 m/s and was higher in patients aged > 50 years (+33.7% vs. < 50 years), those with positive LA (+28.2% vs. LA negative), TAT ≥ 10 μg/l (+18.1% vs. < 10 μg/l), vWF ≥ 200 IU/dl (+51.8% vs. < 200 IU/dl) and with coronary atherosclerosis (CACS > 0; +21.4% vs. CACS = 0). In contrast, the duration of the disease, D-dimers, anticardiolipin, and anti-β2-GPI antibodies did not influence PWV. In the group without atherosclerosis (CACS = 0, n =18), patients with vWF ≥ 200 IU/dl had a 19.3% higher PWV compared to the rest. Conclusions In patients with SLE, PWV was associated with the presence of coronary atherosclerotic lesions in MDCT. Furthermore, arterial stiffness was higher in patients with markers of endothelial dysfunction and a prothrombotic state, suggesting their contribution to the early stages of arterial remodelling in SLE.
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来源期刊
Reumatologia
Reumatologia Medicine-Rheumatology
CiteScore
2.70
自引率
0.00%
发文量
44
审稿时长
10 weeks
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