特发性与缺血性扩张型心肌病的内皮功能评价。

IF 1.3
American journal of cardiovascular disease Pub Date : 2022-06-15 eCollection Date: 2022-01-01
Edoardo Pancaldi, Chiara Tedino, Mauro Riccardi, Fabio Alghisi, Giuliana Cimino, Greta Pascariello, Emiliano Calvi, Edoardo Sciatti, Enrico Vizzardi, Marco Metra
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引用次数: 0

摘要

目的:近年来,内皮功能障碍(ED)在心力衰竭(HF)发病机制中的作用日益引起人们的兴趣。由于心衰的主要病因是缺血性心肌病(ICM),目前尚不清楚与ED的联系是与心衰本身还是与动脉粥样硬化有关。目的是确定与ICM相比,特发性扩张型心肌病(IDCM)受试者中ED的存在。方法:本观察性研究纳入107例患者,其中IDCM 65例,ICM 42例。采用EndoPAT装置对ED进行外周动脉压测。计算反应性充血指数(Reactive hyperemia Index, RHI), RHI值≤1.67,内皮功能正常>2.00(灰色区域在1.67 ~ 2.00之间)建立ED。结果:以RHI≤1.67和RHI≤2.00表达的ED在两组中患病率相似。然而,他们在性别、血脂异常和他汀类药物使用方面存在差异。结论:通过外周动脉血压计评估,内皮功能似乎在IDCM和ICM患者中同样受损。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Endothelial function evaluation in idiopathic vs. ischemic dilated cardiomyopathy.

Aims: In the latest years an emerging interest has risen towards the role of endothelial dysfunction (ED) in the pathogenesis of heart failure (HF) since the very first steps of the disease. Since the prevalent etiology of HF is ischemic cardiomyopathy (ICM), it is still not clear whether the connection with ED is linked to HF itself or to atherosclerosis. The aim is to determine the presence of ED in subjects with idiopathic dilated cardiomyopathy (IDCM) compared to ICM.

Methods: In this observational study 107 patients were enrolled, 65 of them suffering from IDCM and 42 from ICM. ED was assessed as peripheral arterial tonometry by means of EndoPAT device. The Reactive Hyperaemia Index (RHI) was calculated, ED being established with RHI values ≤1.67 and normal endothelial function >2.00 (grey area between 1.67 and 2.00).

Results: ED, expressed both as RHI ≤1.67 and RHI ≤2.00, showed a similar prevalence in the two groups. However, they differed as regards sex, dyslipidemia and statin use.

Conclusion: Endothelial function, evaluated through peripheral artery tonometry, seems equally compromised in patients with IDCM and ICM.

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来源期刊
American journal of cardiovascular disease
American journal of cardiovascular disease CARDIAC & CARDIOVASCULAR SYSTEMS-
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