γ-谷氨酰转移酶与韩国人群头颈癌的关系:一项基于全国人群的研究

IF 3.4
Dong-Hyun Lee, Choung-Soo Kim, Jun-Ook Park, Inn-Chul Nam, Sung Joon Park, Hyun-Bum Kim, Kyungdo Han, Young-Hoon Joo
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引用次数: 0

摘要

背景:γ -谷氨酰转移酶(GGT)与几种癌症类型呈正相关。本研究的目的是在考虑吸烟和饮酒影响的情况下,在1000万人的队列中调查GGT与头颈癌(HNC)发病率之间的关系。方法:本研究所用的所有数据均来自韩国国民健康保险服务数据库。我们分析了2009年接受健康检查的受试者,并对他们进行了监测,直到2018年(n = 9,597,952)。采用比例风险模型,评估GGT的四分位数作为HNC发病率的独立预测因子。结果:高四分位数人群HNC总发病率增高[r-GPT≥40 U/L;人力资源,1.452;95%置信区间(CI), 1.354-1.557]。在HNC病例中,下咽癌的HR为2.364;95% CI(1.818-3.074)显著升高。HNC(喉、鼻、口咽部、口腔和鼻咽部,除唾液腺外)的hr也很显著。结论:GGT升高与某些类型HNCs的发生风险相关,如下咽癌、喉癌、鼻窦癌、口咽癌、口腔癌和鼻咽癌。影响:本研究结果对病因调查和预防策略具有启示意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association between γ-Glutamyltransferase and Head and Neck Cancer in Korean Population: A National Population-Based Study.

Background: Gamma-glutamyltransferase (GGT) is positively associated with several cancer types. The objective of this study was to investigate the association between GGT and head and neck cancer (HNC) incidence in a cohort of 10 million people, considering effects of smoking and alcohol consumption.

Methods: All data used in this study were obtained from the Korean National Health Insurance Service database. We analyzed subjects who underwent health check-ups in 2009 and monitored them until 2018 (n = 9,597,952). Using proportional hazards models, quartiles of GGT as independent predictors for HNC incidence were evaluated.

Results: The overall incidence of HNC increased in the highest quartile [r-GPT ≥ 40 U/L; HR, 1.452; 95% confidence interval (CI), 1.354-1.557]. Among HNC cases, the HR for hypopharyngeal cancer (HR, 2.364; 95% CI, 1.818-3.074) was significantly higher. HRs for HNC (larynx, sino-nasal, oropharynx, oral cavity, and nasopharynx, except salivary glands) were also significant.

Conclusions: Elevated GGT was associated with the risk of some types of HNCs, such as hypopharyngeal, laryngeal, sinonasal, oropharyngeal, oral cavity, and nasopharyngeal cancer.

Impact: Results of this study have implications for etiologic investigations and preventive strategies.

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