骨再生中的骨膜骨干和祖细胞。

IF 5.3 2区 医学
Current Osteoporosis Reports Pub Date : 2022-10-01 Epub Date: 2022-07-13 DOI:10.1007/s11914-022-00737-8
Simon Perrin, Céline Colnot
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引用次数: 11

摘要

综述目的:骨膜是骨的外层,是骨干细胞/祖细胞(SSPCs)用于骨修复的主要来源。在这里,我们讨论了骨膜SSPCs (pSSPCs)在骨再生过程中的表征、作用和调控的最新发现。最近的发现:一些标记物已经被描述为pSSPCs,但缺乏组织特异性。体内谱系追踪和转录组学分析提高了我们对pSSPC在骨再生过程中的功能的理解。骨损伤激活pSSPCs,使其迁移、增殖,并具有形成骨和软骨的独特潜力。骨折环境下,pSSPCs的损伤反应受BMP、FGF、Notch、Wnt等多种信号通路及其代谢状态以及与血凝块、神经纤维、血管、巨噬细胞的相互作用控制。骨膜SSPCs对骨再生至关重要。尽管最近取得了进展,但仍需要进一步的研究来阐明pSSPC的异质性和可塑性,使其成为骨折愈合过程的核心组成部分和临床应用的主要目标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Periosteal Skeletal Stem and Progenitor Cells in Bone Regeneration.

Purpose of review: The periosteum, the outer layer of bone, is a major source of skeletal stem/progenitor cells (SSPCs) for bone repair. Here, we discuss recent findings on the characterization, role, and regulation of periosteal SSPCs (pSSPCs) during bone regeneration.

Recent findings: Several markers have been described for pSSPCs but lack tissue specificity. In vivo lineage tracing and transcriptomic analyses have improved our understanding of pSSPC functions during bone regeneration. Bone injury activates pSSPCs that migrate, proliferate, and have the unique potential to form both bone and cartilage. The injury response of pSSPCs is controlled by many signaling pathways including BMP, FGF, Notch, and Wnt, their metabolic state, and their interactions with the blood clot, nerve fibers, blood vessels, and macrophages in the fracture environment. Periosteal SSPCs are essential for bone regeneration. Despite recent advances, further studies are required to elucidate pSSPC heterogeneity and plasticity that make them a central component of the fracture healing process and a prime target for clinical applications.

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来源期刊
Current Osteoporosis Reports
Current Osteoporosis Reports ENDOCRINOLOGY & METABOLISM-
CiteScore
8.40
自引率
2.30%
发文量
44
期刊介绍: This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of osteoporosis. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as current and future therapeutics, epidemiology and pathophysiology, and evaluation and management. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.
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