氨基酸外溢:使用[177Lu]Lu-DOTATATE进行肽受体放射配体治疗(PRRT)时需要注意的罕见危险信号。

IF 0.6 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

NUCLEAR MEDICINE REVIEW Pub Date : 2022-01-01 Epub Date: 2022-07-18 DOI:10.5603/NMR.a2022.0030

Ghasemali Divband, Seyed Hootan Alavi, Zohre Adinehpour, Forough Kalantari, Soroush Zarehparvar Moghadam

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引用次数: 1

摘要

一位64岁的女性肠神经内分泌肿瘤(NET)合并多发性肝转移，被推荐使用[177Lu]Lu-DOTATATE进行肽受体放射配体治疗(PRRT)。PRRT第三周期后几天，注射部位出现红斑和肿胀，并在治疗后一个月进展。皮肤病变由整形外科医生进行局部治疗。氨基酸外渗可能具有破坏性影响，在接受PRRT和接受氨基酸肾保护的患者中应始终考虑到这一点。

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Amino acid extravasation: a rare red flag to keep in mind during peptide receptor radioligand therapy (PRRT) with [177Lu]Lu-DOTATATE.

A 64 years-old woman with intestinal neuroendocrine tumor (NET) and multiple liver metastases was referred for peptide receptor radioligand therapy (PRRT) with [177Lu]Lu-DOTATATE. A few days after the third cycle of PRRT, erythema and swelling in the injection site is occurred which progressed up to one-month post-therapy. The cutaneous lesion was managed by a plastic surgeon with topical treatment. Amino acid extravasation could have devastating effects and should always be considered in patients who underwent PRRT and who receive amino acids for nephroprotection.

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来源期刊

NUCLEAR MEDICINE REVIEW RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-

CiteScore

1.40

自引率

0.00%

发文量

审稿时长

24 weeks

期刊介绍： Written in English, NMR is a biannual international periodical of scientific and educational profile. It is a journal of Bulgarian, Czech, Hungarian, Macedonian, Polish, Romanian, Russian, Slovak, Ukrainian and Yugoslav Societies of Nuclear Medicine. The periodical focuses on all nuclear medicine topics (diagnostics as well as therapy), and presents original experimental scientific papers, reviews, case studies, letters also news about symposia and congresses. NMR is indexed at Index Copernicus (7.41), Scopus, EMBASE, Index Medicus/Medline, Ministry of Education 2007 (4 pts.).