肿瘤位置对全胃或近端胃切除术患者生活质量的影响。

IF 3.2 4区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
Muneharu Fujisaki, Takashi Nomura, Hiroharu Yamashita, Yoshikazu Uenosono, Tetsu Fukunaga, Eigo Otsuji, Masahiro Takahashi, Hideo Matsumoto, Atsushi Oshio, Koji Nakada
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引用次数: 1

摘要

目的:研究胃切除术后生活质量(QOL)的差异主要基于手术方式或重建方式;只有少数研究比较了基于肿瘤位置的生活质量。本大规模研究旨在探讨食管胃结癌(EGJC)和上三分胃癌(UGC)患者在相同胃切除术后生活质量的差异,以评估肿瘤位置对术后生活质量的影响。方法:采用胃切除术后综合征评估量表-45 (PGSAS-45)对70家机构中因EGJC或UGC而行胃切除术的2364例患者进行问卷调查。共有1909名患者符合研究条件,其中1744名接受了全胃切除术(TG)或近端胃切除术(PG)的患者被选中进行最终分析。患者分为EGJC组和UGC组;之后,比较两组各类型胃切除术的PGSAS-45主要结局指标(mom)。结果:在tg后患者中,UGC组只有一项MOM明显优于EGJC组。相反,在pg后患者中,UGC组19名母亲中有6名的术后生活质量明显好于EGJC组。结论:肿瘤位置对tg后患者术后生活质量影响较小,而pg后患者术后生活质量两组有明显差异。与UGC患者相比,保守估计PG对EGJC患者的益处似乎是合理的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Impact of Tumor Location on the Quality of Life of Patients Undergoing Total or Proximal Gastrectomy.

Impact of Tumor Location on the Quality of Life of Patients Undergoing Total or Proximal Gastrectomy.

Impact of Tumor Location on the Quality of Life of Patients Undergoing Total or Proximal Gastrectomy.

Impact of Tumor Location on the Quality of Life of Patients Undergoing Total or Proximal Gastrectomy.

Purpose: Most studies have investigated the differences in postgastrectomy quality of life (QOL) based on the surgical procedure or reconstruction method adopted; only a few studies have compared QOL based on tumor location. This large-scale study aims to investigate the differences in QOL between patients with esophagogastric junction cancer (EGJC) and those with upper third gastric cancer (UGC) undergoing the same gastrectomy procedure to evaluate the impact of tumor location on postoperative QOL.

Methods: The Postgastrectomy Syndrome Assessment Scale-45 (PGSAS-45) questionnaire was distributed in 70 institutions to 2,364 patients who underwent gastrectomy for EGJC or UGC. A total of 1,909 patients were eligible for the study, and 1,744 patients who underwent total gastrectomy (TG) or proximal gastrectomy (PG) were selected for the final analysis. These patients were divided into EGJC and UGC groups; thereafter, the PGSAS-45 main outcome measures (MOMs) were compared between the two groups for each type of gastrectomy.

Results: Among the post-TG patients, only one MOM was significantly better in the UGC group than in the EGJC group. Conversely, among the post-PG patients, postoperative QOL was significantly better in 6 out of 19 MOMs in the UGC group than in the EGJC group.

Conclusions: Tumor location had a minimal effect on the postoperative QOL of post-TG patients, whereas among post-PG patients, there were definite differences in postoperative QOL between the two groups. It seems reasonable to conservatively estimate the benefits of PG in patients with EGJC compared to those in patients with UGC.

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来源期刊
Journal of Gastric Cancer
Journal of Gastric Cancer Biochemistry, Genetics and Molecular Biology-Cancer Research
CiteScore
4.30
自引率
12.00%
发文量
36
期刊介绍: The Journal of Gastric Cancer (J Gastric Cancer) is an international peer-reviewed journal. Each issue carries high quality clinical and translational researches on gastric neoplasms. Editorial Board of J Gastric Cancer publishes original articles on pathophysiology, molecular oncology, diagnosis, treatment, and prevention of gastric cancer as well as articles on dietary control and improving the quality of life for gastric cancer patients. J Gastric Cancer includes case reports, review articles, how I do it articles, editorials, and letters to the editor.
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