血清Afamin水平与非酒精相关性脂肪肝的关系

IF 2.7 4区 医学 Q2 Medicine
Canadian Journal of Gastroenterology and Hepatology Pub Date : 2022-06-28 eCollection Date: 2022-01-01 DOI:10.1155/2022/7175108
Shenghui Chen, Zhening Liu, Li Cen, Jinghua Wang, Juanwen Zhang, Xiaofeng Zhang, Chengfu Xu
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引用次数: 2

摘要

Afamin是与多种代谢疾病密切相关的肝因子中的一员。维生素与非酒精性脂肪性肝病(NAFLD)之间的关系尚不清楚。本研究旨在探讨血清afamin水平与NAFLD的相关性。我们分析了88名NAFLD患者和88名年龄和性别匹配的健康对照,他们在浙江大学医学院第一附属医院接受了健康检查。在22例活检证实的NAFLD患者和36例健康对照中进一步证实了这种关联。采用酶联免疫吸附试验(ELISA)评估血清afamin水平。NAFLD患者血清afamin水平显著高于健康对照组(14.79±5.04 mg/L vs 10.83±3.24 mg/L);P < 0.001)。血清维生素a水平与代谢参数(包括体重指数、腰围、收缩压、肝酶和脂质谱)呈正相关。多元回归分析显示血清afamin水平与NAFLD风险独立相关(OR: 1.289, 95% CI: 1.141-1.456;P < 0.001)。受试者工作特征(ROC)分析显示,血清afamin加BMI检测NAFLD的曲线下面积(AUC)为0.878。在接受肝活检的参与者中,血清维生素a和BMI检测到NAFLD的AUC为0.758。综上所述,血清afamin水平与NAFLD的患病率和风险呈正相关,血清afamin加上BMI对NAFLD具有较高的诊断效能。本研究提供了NAFLD中维生素a的流行病学证据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Association Between Serum Afamin Levels with Nonalcoholic Associated Fatty Liver Disease.

Association Between Serum Afamin Levels with Nonalcoholic Associated Fatty Liver Disease.

Association Between Serum Afamin Levels with Nonalcoholic Associated Fatty Liver Disease.

Association Between Serum Afamin Levels with Nonalcoholic Associated Fatty Liver Disease.

Afamin is a member of the hepatokine that are strongly associated with various metabolic diseases. The relationship between afamin and nonalcoholic fatty liver disease (NAFLD) remains unclear. This study aimed to explore the correlation between serum afamin levels and NAFLD. We analyzed 88 NAFLD patients and 88 age- and sex-matched healthy controls who took their health examinations at the First Affiliated Hospital, Zhejiang University School of Medicine. The association was further confirmed in 22 biopsy-confirmed NAFLD patients and 36 healthy controls. Serum afamin levels were evaluated using an enzyme-linked immunosorbent assay (ELISA). NAFLD patients had significantly higher serum afamin levels than the healthy controls (14.79 ± 5.04 mg/L versus 10.83 ± 3.24 mg/L; P < 0.001). Serum afamin levels were positively correlated with metabolic parameters including the body mass index, waist circumference, systolic blood pressure, liver enzymes, and lipid profiles. A multiple regression analysis showed that serum afamin levels were independently related to the risk of NAFLD (OR: 1.289, 95% CI, 1.141-1.456; P < 0.001). The receiver operating characteristic (ROC) analysis showed that the area under curve (AUC) of serum afamin plus the BMI for detecting NAFLD was 0.878. In participants with liver biopsies, the serum afamin plus the BMI detected NAFLD with an AUC of 0.758. In conclusion, serum afamin levels were positively associated with prevalence and risk of NAFLD, and serum afamin plus the BMI had a high diagnostic performance for NAFLD. This study provides epidemiological evidence of afamin in NAFLD.

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来源期刊
CiteScore
4.80
自引率
0.00%
发文量
0
审稿时长
37 weeks
期刊介绍: Canadian Journal of Gastroenterology and Hepatology is a peer-reviewed, open access journal that publishes original research articles, review articles, and clinical studies in all areas of gastroenterology and liver disease - medicine and surgery. The Canadian Journal of Gastroenterology and Hepatology is sponsored by the Canadian Association of Gastroenterology and the Canadian Association for the Study of the Liver.
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